Hydrogel for light delivery in biomedical applications.

Traditional optical waveguides or mediums are often silica-based materials, but their applications in biomedicine and healthcare are limited due to the poor biocompatibility and unsuitable mechanical properties. In term of the applications in human body, a biocompatible hydrogel system with excellent optical transparency and mechanical flexibility could be beneficial. In this review, we explore the different designs of hydrogel-based optical waveguides derived from natural and synthetic sources.

Nanochitin for sustainable and advanced manufacturing.

Presently, the rapid depletion of resources and drastic climate change highlight the importance of sustainable development. In this case, nanochitin derived from chitin, the second most abundant renewable polymer in the world, possesses numerous advantages, including toughness, easy processability and biodegradability. Furthermore, it exhibits better dispersibility in various solvents and higher reactivity than chitin owing to its increased surface area to volume ratio.

PVA/pectin composite hydrogels inducing osteogenesis for bone regeneration.

Hydrogels composed from biomolecules have gained great interests as biomaterials for tissue engineering. However, their poor mechanical properties limit their application potential. Here, we synthesized a series of tough composite hydrogels from poly (vinyl alcohol) (PVA) and pectin for bone tissue engineering.

Hydrogel-Based Flexible Electronics.

Flexible electronics is an emerging field of research involving multiple disciplines, which include but not limited to physics, chemistry, materials science, electronic engineering, and biology. However, the broad applications of flexible electronics are still restricted due to several limitations, including high Young's modulus, poor biocompatibility, and poor responsiveness. Innovative materials aiming for overcoming these drawbacks and boost its practical application is highly desirable.

Dynamic Grafting of Carboxylates onto Poly(Vinyl Alcohol) Polymers for Supramolecularly-Crosslinked Hydrogel Formation.

Supramolecular hydrogels have attracted considerable interest due to their unique stimuli-responsive and self-healing properties. However, these hydrogel systems are usually achieved by covalent grafting of supramolecular units onto the polymer backbone, which in turn limits their reprocessability. Herein, we prepared a supramolecular hydrogel system by forming dynamic covalent crosslinks between 4-carboxyphenylboronic acid (CPBA) and polyvinyl alcohol (PVA).

A New Potent Antimicrobial Metalloporphyrin.

A series of bis-acryl functionalized porphyrins and their corresponding metalloporphyrins (M=Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile.

Recycling of spent coffee grounds for useful extracts and green composites.

Large amounts of spent coffee grounds (SCGs) are often discarded and there is a need to find alternative disposal methods due to environmental concerns. This project aims to develop sustainable materials by re-purposing spent coffee grounds (SCGs). Oil extraction was performed using different organic solvents and yielded approximately 10% coffee oil.

Sanitizing agents for virus inactivation and disinfection.

Viral epidemics develop from the emergence of new variants of infectious viruses. The lack of effective antiviral treatments for the new viral infections coupled with rapid community spread of the infection often result in major human and financial loss. Viral transmissions can occur via close human-to-human contact or via contacting a contaminated surface.

Recent innovations in artificial skin.

The skin is a "smart", multifunctional organ that is protective, self-healing and capable of sensing and many forms of artificial skins have been developed with properties and functionalities approximating those of natural skin. Starting from specific commercial products for the treatment of burns, progress in two fields of research has since allowed these remarkable materials to be viable skin replacements for a wide range of dermatological conditions. This review maps out the development of bioengineered skin replacements and synthetic skin substitutes, including electronic skins.

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment.

Artificial skin devices are able to mimic the flexibility and sensory perception abilities of the skin. They have thus garnered attention in the biomedical field as potential skin replacements. This Review delves into issues pertaining to these skin-deep devices.

Micellized α-Cyclodextrin-Based Supramolecular Hydrogel Exhibiting pH-Responsive Sustained Release and Corresponding Oscillatory Shear Behavior Analysis.

The fabrication of supramolecular hydrogels from micellized PLLA/DMAEMA/PEGMA polymers with α-CD has been explored to design injectable gel formulations for sustained drug release. The tricomponent hydrogels (5% w/v)/α-CD (10% w/v) were able to sustain protein (BSA and lysozyme) release for 60-120 h at different pH conditions (pH 3, 7 and 10). In-depth rheological analysis highlighted the role of pH in tuning hydrogel behavior upon shear at microscopic level affecting protein release profiles.

Supramolecular cyclodextrin pseudorotaxane hydrogels: a candidate for sustained release?

In this work, PEO-α-CD pseudorotaxane hydrogels were prepared. The gels were loaded with proteins, BSA and lysozyme, representing proteins with different molecular weights. The kinetics of protein release was studied.