Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers.

Objective: The purpose of this study was to determine the effects of enamel matrix derivative on mRNA expression of markers related to periodontal healing.

Study Design: Murine osteoprogenitor cells (MC3T3-E1) were grown for 12 and 16 days in mineralization media and stimulated with 100 microg/mL Emdogain (EMD). Cell cultures treated with 2% and 10% fetal calf serum (FCS) served as control.