Unusual triskelion patterns and dye-labelled GUVs: consequences of the interaction of cholesterol-containing linear-hyperbranched block copolymers with phospholipids.

Cholesterol (Ch) linked to a linear-hyperbranched block copolymer composed of poly(ethylene glycol) (PEG) and poly(glycerol) (hbPG) was investigated for its membrane anchoring properties. Two polyether-based linear-hyperbranched block copolymers with and without a covalently attached rhodamine fluorescence label (Rho) were employed (Ch-PEG30-b-hbPG23 and Ch-PEG30-b-hbPG17-Rho). Compression isotherms of co-spread 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with the respective polymers were measured on the Langmuir trough and the morphology development of the liquid-condensed (LC) domains was studied by epi-fluorescence microscopy.

Interactions of DPPC with semitelechelic poly(glycerol methacrylate)s with perfluoroalkyl end groups.

Semitelechelic poly(glycerol methacrylate)s having a perfluoroalkyl end group (PGMA(n)-F(9)) were synthesized by ATRP. The interactions of these polymers with different degrees of polymerization with chiral or racemic dipalmitoylphosphatidylcholine (l-DPPC, d-DPPC, or rac-DPPC) monolayers at the air/water interface were studied. Langmuir trough measurements coupled with epifluorescence microscopy allowed for the observation of domain formation within the coexistence region of liquid-expanded (LE) and liquid-condensed (LC) states of DPPC in mixed DPPC-polymer films prepared by spreading a solution of both compounds in the same organic solvent (cospread films).

Controlling the localization of polymer-functionalized nanoparticles in mixed lipid/polymer membranes.

Surface hydrophobicity plays a significant role in controlling the interactions between nanoparticles and lipid membranes. In principle, a nanoparticle can be encapsulated into a liposome, either being incorporated into the hydrophobic bilayer interior or trapped within the aqueous vesicle core. In this paper, we demonstrate the preparation and characterization of polymer-functionalized CdSe NPs, tuning their interaction with mixed lipid/polymer membranes from 1,2-dipalmitoyl-sn-glycero-3-phophocholine and PIB(87)-b-PEO(17) block copolymer by varying their surface hydrophobicity.

A T-shaped amphiphilic molecule forms closed vesicles in water and bicelles in mixtures with a membrane lipid.

The T-shaped amphiphilic molecule A6/6 forms a columnar hexagonal liquid-crystalline phase between the crystalline and the isotropic liquid when studied in bulk (Chen et al., 2005). Because of the hydrophilic and flexible oligo(oxyethylene) side chain terminated by a 1-acylamino-1-deoxy-d-sorbitol moiety attached to a rigid terphenyl core with terminal hexyloxy alkyl chains, it was expected that also formation of lyotropic phases could be possible.