Publications by authors named "Peggy K Crow"
Article Synopsis
- PLZF is a transcription factor that influences the development and function of specific immune cells, including invariant NKT cells and certain γδ T cells in mice, but its role in humans is broader.
- In humans, PLZF is expressed in significant percentages of CD8+ and CD4+ T cells, as well as all γδ T cells and NK cells, indicating its importance across various lymphocyte populations.
- A lack of functional PLZF in a donor resulted in alterations across these lymphocyte types, and while PLZF-expressing CD8+ T cells increased in melanoma patients, they decreased in those with autoimmune diseases.
