Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

Tuberous Sclerosis Complex (TSC) is a multiorgan genetic disease that prominently features brain malformations (tubers) with many patients suffering from epilepsy and autism. These malformations typically exhibit neuronal as well as glial cell abnormalities and likely underlie much of the neurological morbidity seen in TSC. Tuber pathogenesis remains poorly understood though upregulation of the mTORC1 signaling pathway in TSC has been consistently demonstrated.

Morphometric analysis of fibre cell growth in the developing chicken lens.

The optical characteristics of any lens are determined by its internal composition, size and shape. In the lens of the eye, the macroscopic form of the tissue reflects the arrangement and behaviour of its component cells. In the current study, we quantified changes in the morphology and organization of chicken lens fibre cells during embryonic development.