Publications by authors named "Pegah S Mirshahidi"
Neurons express various combinations of neurotransmitter receptor (NR) subunits and receive inputs from multiple neuron types expressing different neurotransmitters. Localizing NR subunits to specific synaptic inputs has been challenging. Here, we use epitope-tagged endogenous NR subunits, expansion light-sheet microscopy, and electron microscopy (EM) connectomics to molecularly characterize synapses in Drosophila.
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- Neurons integrate various neurotransmitter signals and localizing specific receptor subunits to synaptic inputs is complicated.
- Utilizing advanced microscopy and genetic techniques in Drosophila, the study reveals distinct molecular configurations of neurotransmitter receptors at specific synaptic sites of motion-sensitive neurons.
- Findings suggest that the spatial distribution of these receptors and associated proteins influences how synapses are formed and which neuron types connect, essentially acting as a "map" for synaptic connectivity.