Publications by authors named "Pegah Rahmati Nezhad"
Article Synopsis
- Cutaneous squamous cell carcinoma (cSCC) is the most common type of skin cancer that can spread to other parts of the body, and it shows a link between complement components and cancer growth.* -
- Research found that factor D (FD), an enzyme in the alternative complement pathway, is significantly more active and produced in cSCC cells compared to normal skin cells, indicating its role in cSCC development.* -
- The study highlights FD as a potential new biomarker and target for therapy, showing that blocking FD can reduce cSCC cell growth by affecting key signaling pathways.*
The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing globally. Here, we have studied the functional role of complement factor I (CFI) in the progression of cSCC. CFI was knocked down in cSCC cells, and RNA-seq analysis was performed.
View Article and Find Full Text PDFEpidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with high mortality rates in the advanced stage. Chronic inflammation is a recognized risk factor for cSCC progression and the complement system, as a part of innate immunity, belongs to the microenvironment of tumors. The complement system is a double-edged sword in cancer, since complement activation is involved in anti-tumor cytotoxicity and immune responses, but it also promotes cancer progression directly and indirectly.
View Article and Find Full Text PDFBackground: This study aimed at evaluating HRCT pulmonary manifestations in children with Common Variable Immunodeficiency (CVID) hospitalized in the Pediatric Ward of Masih Daneshvari Hospital during a 10-year period.
Materials And Methods: This retrospective study evaluated 25 children hospitalized with the diagnosis of CVID in the Pediatric Ward of Masih Daneshvari Hospital from 2001 to 2011 and their pulmonary HRCT scans were evaluated.
Results: The most common pulmonary HRCT findings were lymphadenopathy (66.