Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair.

Catechol-modified bioadhesives generate hydrogen peroxide (HO) during the process of curing. A robust design experiment was utilized to tune the HO release profile and adhesive performance of a catechol-modified polyethylene glycol (PEG) containing silica particles (SiP). An L orthogonal array was used to determine the relative contributions of four factors (the PEG architecture, PEG concentration, phosphate-buffered saline (PBS) concentration, and SiP concentration) at three factor levels to the performance of the composite adhesive.

Hydroxyl Radical Generation Through the Fenton-Like Reaction of Hematin- and Catechol-Functionalized Microgels.

Hydroxyl radical (OH) is a potent reactive oxygen species with the ability to degrade hazardous organic compounds, kill bacteria, and inactivate viruses. However, an off-the-shelf, portable, and easily activated biomaterial for generating OH does not exist. Here, microgels were functionalized with catechol, an adhesive moiety found in mussel adhesive proteins, and hematin (HEM), a hydroxylated Fe ion-containing porphyrin derivative.

Controlling the Release of Hydrogen Peroxide from Catechol-Based Adhesive Using Silica Nanoparticle.

Catechol-based bioadhesives generate hydrogen peroxide (HO) as a byproduct during the curing process. HO can have both beneficial and deleterious effects on biological systems depending on its concentration. To control the amount of HO released from catechol-containing polyethylene glycol-based adhesive (PEG-DA), adhesive was formulated with silica nanoparticles (SiNP) prepared with increased porosity and acid treatment to increase Si-OH surface content.

Design of pH-responsive SAP polymer for pore solution chemistry regulation and crack sealing in cementitious materials.

The crack development is considered to be one of the most severe threats to the durability of concrete infrastructure. This study aims to enhance the durability performance of cementitious material with the pH-responsive Superabsorbent Polymer (SAP). The SAP was synthesized with acrylic acid (AA)-methyl acrylate (MA) precursors, and three type samples with different crosslinking levels were prepared.

Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.

Hydrogels are a unique class of polymeric materials that possess an interconnected porous network across various length scales from nano- to macroscopic dimensions and exhibit remarkable structure-derived properties, including high surface area, an accommodating matrix, inherent flexibility, controllable mechanical strength, and excellent biocompatibility. Strong and robust adhesion between hydrogels and substrates is highly desirable for their integration into and subsequent performance in biomedical devices and systems. However, the adhesive behavior of hydrogels is severely weakened by the large amount of water that interacts with the adhesive groups reducing the interfacial interactions.

Antibacterial Properties of Mussel-Inspired Polydopamine Coatings Prepared by a Simple Two-Step Shaking-Assisted Method.

A simple two-step, shaking-assisted polydopamine (PDA) coating technique was used to impart polypropylene (PP) mesh with antimicrobial properties. In this modified method, a relatively large concentration of dopamine (20 mg ml) was first used to create a stable PDA primer layer, while the second step utilized a significantly lower concentration of dopamine (2 mg ml) to promote the formation and deposition of large aggregates of PDA nanoparticles. Gentle shaking (70 rpm) was employed to increase the deposition of PDA nanoparticle aggregates and the formation of a thicker PDA coating with nano-scaled surface roughness (RMS = 110 nm and Ra = 82 nm).

Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein.

Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhesion to various substrate surfaces and contributes to the curing of the adhesive plaques.