Primary outcome reporting in clinical trials for older adults with depression.

Background: Findings from randomised controlled trials (RCTs) are synthesised through meta-analyses, which inform evidence-based decision-making. When key details regarding trial outcomes are not fully reported, knowledge synthesis and uptake of findings into clinical practice are impeded.

Aims: Our study assessed reporting of primary outcomes in RCTs for older adults with major depressive disorder (MDD).

Heterogeneity across outcomes reported in clinical trials for older adults with depression: a systematic survey.

Objectives: The objective of our study was to identify outcomes reported in trials for older adults with depression and describe outcome heterogeneity.

Study Design And Setting: We searched four databases to identify trials assessing any intervention for major depressive disorder among older adults published between 2011 and 2021. We grouped reported outcomes thematically and mapped them onto core outcome areas (physiological/clinical, life impact, resource use, adverse events, and death) and used descriptive analysis to summarize outcome heterogeneity.