Publications by authors named "Peetra Ulrica Magnusson"
Article Synopsis
- Cerebral cavernous malformation (CCM) is a rare neurovascular condition affecting about 0.5% of people, with recent research shifting focus from genetic causes to the role of the hemostatic system and neuroinflammation in its severity.
- This review highlights the interactions between endothelial cells lacking CCM and blood components, demonstrating how endothelial dysfunction can lead to issues like bleeding, hypoxia, and neurological symptoms.
- The findings suggest a need to view CCM as a hemostatic disease, which could influence future treatment approaches.
Cerebral cavernous malformation (CCM) is a rare neurovascular disease that is characterized by enlarged and irregular blood vessels that often lead to cerebral hemorrhage. Loss-of-function mutations to any of three genes results in CCM lesion formation; namely, , , and . Here, we report for the first time in-depth single-cell RNA sequencing, combined with spatial transcriptomics and immunohistochemistry, to comprehensively characterize subclasses of brain endothelial cells (ECs) under both normal conditions and after deletion of ( in a mouse model of CCM.
View Article and Find Full Text PDFObjective: The purpose of this study was to clarify the role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in hematopoietic/endothelial development.
Methods And Results: Using several different FGFR-1-specific antibodies and FGFR-1 promoter-driven LacZ activity, we show that FGFR-1 is expressed and active as a tyrosine kinase in a subpopulation of endothelial cells (approximately 20% of the endothelial pool) during development in embryoid bodies. In agreement, in stem cell-derived teratomas, expression of FGFR-1 was detected in some but not all vessels.