Publications by authors named "Peer N"

Objectives: The objective of this study was to explore how Ontario Public Health Units (PHUs) partnered with faith-based organizations (FBOs) and other community-based organizations (CBOs) to promote COVID-19 vaccination among ethnoracial groups made structurally vulnerable during the pandemic, and to understand how PHUs perceive the effectiveness of these partnerships with these organizations.

Methods: Between June to December 2022, we distributed a cross-sectional survey to 34 PHUs in Ontario to explore how PHUs were engaging and partnering with FBOs and CBOs.

Results: Responses were received from 28 of 34 (82.

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Cofactor F is an electron carrier playing a crucial role in a variety of microorganisms during redox reactions of the primary and secondary metabolism due to its low redox potential and thus arouses increasing interest. In this study, cofactor F glutamyl tail length spectra in various habitats like manure, compost, soil, and digester sludge samples and their respective microbial communities were investigated using high performance liquid chromatography and an amplicon sequencing approach A previous study was used to identify F producing microorganisms. The highest concentration of cofactor F could be achieved in the horse manure, digester sludge, and mixed manure samples, which was approximately 100-fold higher than in all the other samples.

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Background: Equitable access to vaccination remains a concern, particularly among population groups made structurally vulnerable. These population groups reflect the diversity of communities that are confronted with structural barriers caused by systemic racism and oppression and result in them experiencing suffer disadvantage and discrimination based on citizenship, race, ethnicity, ancestry, religion, spiritual beliefs, and/or gender identity. In Canada, Ontario public health units (PHUs) engage with faith-based organizations (FBOs) to improve vaccine confidence among populations made structurally vulnerable.

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This study examined the associations between tobacco smoking and serum cotinine levels, an objective biochemical measure of tobacco smoke exposure, with markers of inflammation, i.e., interferon-gamma (IFN-γ), interleukin 10 (IL-10), interleukin 2 (IL-2) and tumour necrosis factor-alpha (TNF-α) in people living with HIV (PLWH).

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Article Synopsis
  • The study aims to evaluate how effective various traditional and novel body measurement indices are in predicting the risk of type 2 diabetes mellitus (T2D) in South African adult females.
  • Researchers analyzed data from the South African National Health and Nutrition Examination Survey, focusing on factors like body mass index (BMI) and waist circumference, and used diagnostic criteria to identify newly diagnosed T2D cases.
  • Results showed higher average values for all anthropometric indices in individuals with T2D, indicating a significant association; particularly, waist circumference and abdominal volume index were strongly linked to increased odds of T2D even after accounting for other demographic variables.
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Implantable devices hold the potential to address conditions currently lacking effective treatments, such as drug-resistant neural impairments and prosthetic control. Medical devices need to be biologically compatible while providing enhanced performance metrics of low-power consumption, high accuracy, small size, and minimal latency to enable ongoing intervention in brain function. Here, we demonstrate a memristor-based processing system for single-trial detection of behaviorally meaningful brain signals within a timeframe that supports real-time closed-loop intervention.

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  • * Data from 2,772 ART-naïve adults were analyzed, revealing a CKD prevalence of 10.0% to 17.6%; the study found that older age and factors such as anemia, lower BMI, and low CD4 counts were significantly associated with CKD.
  • * Three methods for estimating CKD (BSA-CG, MDRD, and CKD-EPI) were compared, with
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  • Multimorbidity means having two or more long-lasting health problems at the same time, and it's becoming a big issue for health care around the world.
  • A group of 60 researchers from 10 African countries worked together to figure out if the idea of multimorbidity is useful in Africa and how it can be adapted to fit local needs.
  • During their workshop, they talked about different perspectives on multimorbidity and came up with new ideas that focus on what people really need and the impact it has on their lives and health systems.
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Background: The association between HIV infection and increased cardiometabolic risk, attributed to chronic inflammation in people living with HIV (PLWH) and/or antiretroviral therapy (ART) effects, has been inconsistent. In this study, we aimed to assess the associations of HIV-related factors with hypertension (HTN) and type-2 diabetes mellitus (T2DM), and the potential mediation effects of body mass index (BMI) in the associations between ART use and HTN or T2DM in PLWH in Cameroon.

Methods: A cross-sectional study was conducted with 14,119 adult PLWH from Cameroon enrolled in the International epidemiology Databases to Evaluate AIDS (IeDEA) between 2016 and 2021.

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Background: Dyslipidaemia and hypertension care have not been reported in large samples of community-based participants with known diabetes (KD) nor compared with individuals at high risk for diabetes.

Objectives: To describe the management and associations of dyslipidaemia and hypertension in adults with KD, newly diagnosed diabetes (NDD) and normoglycaemia.

Methods: This urban population-based cross-sectional study comprised participants with KD, NDD and normoglycaemia.

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During the present study, the evolutionary relationship within a clade of mountain clade of freshwater crabs () was examined using mtDNA sequence data for species from the Cape Fold Mountain (CFM) and Great Escarpment (Drakensberg Mountain range). We undertook phylogenetic analyses, divergence time estimation, and an ancestral area reconstruction to explore the period of cladogenesis and understand the biogeographic history in this high-altitude clade. Furthermore, we applied four species delimitation methods using ASAP, bPTP, bGMYC, and STACEY on the latter clade.

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Emerging evidence suggests that the addition of text messages to standard healthy lifestyle interventions may improve the outcomes of diabetes prevention programs (DPP). This paper describes the process of developing text messages targeting behavior change in people at risk of developing diabetes in low-resourced communities as part of the South African DPP (SA-DPP). The development comprised multiple steps led by nutrition and physical activity experts.

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Article Synopsis
  • The study investigates the prevalence and factors contributing to hypertension among people living with HIV who haven't started antiretroviral therapy in a large clinic in Lagos, Nigeria.
  • It analyzed data from over 10,000 participants, primarily women aged 25-49, finding a crude hypertension prevalence of 16.8%, with higher rates in males (25.8%) compared to females (18.3%).
  • Key risk factors for hypertension included older age, male gender, being overweight or obese, and existing diabetes or kidney issues, indicating a need for regular hypertension screening in HIV care.
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Microplastic (MP) prevalence has been well documented, however, knowledge gaps exist for African mangrove forests. This research is the first to compare MP pollution (using FT-IR analysis) in an urban (Durban Bay) and peri-urban (Mngazana Estuary) mangrove forest in South Africa, across different compartments. MP pollution (typology, abundance, and distribution) was quantified in estuarine surface water, sediment and the soft tissue of three keystone species (Austruca occidentalis, Chiromantes eulimene and Cerithidea decollata) in relation to disturbances acting on these systems.

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Survivors of sexual violence are at higher risk of adverse mental health outcomes compared to those exposed to other interpersonal traumas. To examine the trajectory of both post-traumatic stress disorder (PTSD) and depression as well as the role of early counselling over 24 months among rape survivors. The South African Rape Impact Cohort Evaluation (RICE) study enrolled women aged 16-40 years attending post-rape care services within 20 days of a rape incident ( = 734), and a comparison group ( = 786) was recruited from primary health care.

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Introduction: To determine the incidence, management and outcomes of esophageal atresia/tracheo-esophageal fistula (EA/TEF) over a 15-y period in South Africa.

Methods: A retrospective chart review of neonates with EA/TEF presenting at the main tertiary referral hospital in the KwaZulu-Natal province between 2002 and 2017 was conducted. Data collection comprised patient and maternal demographics, clinical presentations, laboratory and radiologic investigations, surgical procedures, and outcomes.

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Introduction: over one third of total Disability-Adjusted-Life-Years lost in Kenya are due to non-communicable diseases (NCD). In response, the Government declared significant commitment towards improving NCD care. The COVID-19 pandemic increased the burden on the already overstretched health systems in Kenya.

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Background: The association of traumatic experiences with problematic alcohol use has been described, but data on possible mediation effects of mental distress are sparse. We examined whether mental ill-health mediated the association between trauma exposure across the lifespan and alcohol use.

Method: We analysed cross-sectional data from a sample of rape-exposed and non-rape-exposed women, living in KwaZulu-Natal, with self-reported data on alcohol misuse (AUDIT-C cut-off ≥ 3) and exposure to childhood maltreatment (CM), intimate partner violence (IPV), non-partner sexual violence (NPSV), other traumatic events, and mental ill-health.

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Article Synopsis
  • - The study explores the views of Malaysian health professionals on how non-communicable disease (NCD) services were disrupted during the COVID-19 pandemic from March 2020 to January 2022, using an online survey with 191 health workers.
  • - Participants highlighted significant issues like the redirection of resources and the burden on NCD care following the pandemic, but also noted the healthcare system's resilience and need for innovation.
  • - While many respondents felt that challenges were mostly managed effectively, the study reveals gaps in the health system's response and suggests improvements for better NCD service delivery in the future.
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Introduction: People living with HIV/AIDS (PLHIV) are at increased risk of cardiometabolic diseases attributable to the effects of the virus, antiretroviral therapy (ART) and traditional risk factors. Most studies have focused on assessing the effect of ART on cardiometabolic diseases in PLHIV with fewer studies assessing the cardiometabolic risk profile prior to exposure to ART. Therefore, this protocol is for a systematic review and meta-analysis to estimate the global prevalence of selected cardiometabolic risk factors in ART-naïve PLHIV and their association with HIV specific factors.

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A new species of freshwater crab, , is described from the Winterberg-Amathole mountain range in the Eastern Cape Province, South Africa. Morphologically, Peer & Gouws, most closely resembles but can be distinguished by key morphological characters including the variation in the shape of the subterminal segment of gonopod 2 between both species. Genetically, Peer & Gouws, is placed within the clade of small-bodied, mountain-dwelling crabs including , , , , , and .

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Adverse pregnancy outcomes (APOs) are common occurrences that contribute to negative maternal and child health outcomes. Our aim was to test the hypothesis that trauma exposure and depression are drivers of the better-recognised risk factors for miscarriage, abortion and stillbirths. Our comparative cohort study based in Durban, South Africa recruited women who reported a recent rape (n = 852) and those who had never experienced rape (n = 853), with follow-up for 36 months.

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Introduction: In people living with human immunodeficiency virus (PLHIV), traditional cardiovascular risk factors, exposure to HIV per se and antiretroviral therapy (ART) are assumed to contribute to cardiometabolic diseases. Nevertheless, controversy exists on the relationship of HIV and ART with diabetes. To clarify the relationship between HIV and type 2 diabetes, this review determined, in PLHIV in Africa, diabetes and prediabetes prevalence, and the extent to which their relationship was modified by socio-demographic characteristics, body mass index (BMI), diagnostic definitions used for diabetes and prediabetes, and HIV-related characteristics, including CD4 count, and use and duration of ART.

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The South African Diabetes Prevention Programme (SA-DPP) is a lifestyle intervention targeting individuals at high risk of developing type 2 diabetes mellitus (T2DM). In this paper we describe the mixed-method staged approach that was used to develop and refine the SA-DPP intervention curriculum and the appropriate tools for local resource-poor communities. During the preparation phase, existing evidence on similar DPP interventions was reviewed, focus group discussions with individuals from the target population were conducted as part of a needs assessment, and experts were consulted.

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Since the start of the 2019 pandemic, wastewater-based epidemiology (WBE) has proven to be a valuable tool for monitoring the prevalence of SARS-CoV-2. With methods and infrastructure being settled, it is time to expand the potential of this tool to a wider range of pathogens. We used over 500 archived RNA extracts from a WBE program for SARS-CoV-2 surveillance to monitor wastewater from 11 treatment plants for the presence of influenza and norovirus twice a week during the winter season of 2021/2022.

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