Pseudomonas-induced scleritis mimicking autoimmune necrotizing scleritis. A case report.

To report a case of spontaneous-onset unilateral scleritis and keratitis due to Pseudomonas aeruginosa in a patient with systemic lupus erythematosus who partially responded to antibiotic therapy and achieved complete resolution after IV immunotherapy. A 30-year-old woman with a past medical history of hypothyroidism and systemic lupus erythematosus and on irregular therapy presented with a long-history of thinning of the sclera and cornea refractory to antibiotic therapy despite a positive culture for P. aeruginosa, which eventually resolved with the implementation of immunotherapy.

Clinical Profile, Systemic Association, Treatment and Visual Outcome of Patients with Scleritis in an Eye Care Center in Mexico City.

Aims: To describe demographic and clinical characteristics as well as etiologies and visual outcomes of patients with scleritis.

Methods: This is a descriptive, observational and retrospective study. We reviewed the electronic health records of patients with diagnosis of scleritis, who presented at the Institute of Ophthalmology Conde de Valenciana from January 2009 to December 2019.

Outcomes of cataract surgery with/without vitrectomy in patients with pars planitis and immunosuppressive therapy.

Background: The purpose of this study was to evaluate the characteristics and outcomes of cataract surgery with/without vitrectomy in patients with pars planitis who received immunosuppressive therapy.

Methods: This was a retrospective case series, single-center study. Twenty-two patients with pars planitis who received immunosuppressive therapy were included, with a median age at presentation of 9.

Sclerodermatomyositis, ocular manifestations.

Background: Sclerodermatomyositis is an overlap syndrome of myositis and scleroderma, with dermatological, muscular and joint involvement, but may also present with ocular manifestations.

Clinical Case: A 57 year-old woman presented with ophthalmological manifestations, including scleral thinning 360°, and the presence of cells in the anterior and posterior chamber. Oriented physical examination and laboratory studies led to the diagnosis, with the need for systemic treatment.

Characteristics of Sympathetic Ophthalmia in a Single International Center.

Aim: To report the main features of sympathetic ophthalmia in a referral ophthalmology center.

Methods: Retrospective clinical study. We reviewed clinical records of patients with diagnosis of sympathetic ophthalmia attending the Uveitis Department from 2007 to 2013.

[Vogt-Koyanagi-Harada syndrome].

The Vogt-Koyanagi-Harada syndrome is a disease with dermatological, neurologic and auditory findings, associated with a bilateral granulomatous panuveitis. We present the case of a 42-year-old woman who started with ophthalmic manifestations, and in a late follow-up she developed the characteristic dermatological findings.

Ultrasound biomicroscopic analysis of iris cysts.

Purpose: To describe the ultrasound biomicroscopic (UBM) features and complications associated with iris cysts.

Design: A retrospective case series.

Methods: Thirteen patients with iris cysts were identified in a 10 year period study at a ophthalmologic reference Center in Mexico City.

Treatment with immunosuppressive therapy in patients with pars planitis: experience of a reference centre in Mexico.

Aim: To evaluate the clinical course of the patients with pars planitis that received immunosuppressive drugs.

Methods: We retrospectively analysed the data of 10 years from 374 patients with pars planitis in a large reference centre in Mexico City and included 49 patients (92 eyes).

Results: Median age at presentation was 8 years.

[Clinical course of pars planitis in patients treated with selective photocoagulation].

Introduction: Pars planitis is an intermediate uveitis with bilateral and asymmetric presentation. The etiology is unknown and pathogenesis is unclear. Treatment follows the algorithm of Foster, which includes selective photocoagulation.

Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells.

Aim: To evaluate the frequency, phenotype and the potential function of CD57+ T cell subsets in patients with pars planitis.

Methods: CD4+CD57+ and CD8+CD57+ T cells were quantitated in peripheral blood from 15 patients with pars planitis and 15 healthy controls. To evaluate the phenotype and potential function of CD57+ T cell subsets CCR7, CD27, CD28, CD45RA, CD45RO, intracellular IFN-gamma, IL-4, perforin and granzyme-A expression were assessed by flow cytometry.

[Uveitis immunopathology: currents knowledge, clinical correlation and research perspectives in the immue-ocular area].

The eye has multiple mechanisms of immune regulation implicated in the maintenance of ocular immune privilege. However, sometimes diseases or disorders appear and can cause clinical manifestations of intraocular inflammation; usually those diseases are collectively named "uveitis". Despite the uveitis is the main cause of eye morbidity and lost of visual function, the vast majority of the immune mechanisms involved in its generation remains unknown.

[Diagnosis of Wegener's granulomatosis in patients with ocular inflamatory disease].

Objective: Report the ophthalmologic manifestations among patients with Wegener 's Granulomatosis (WG).

Method: We reviewed the database of the Instituto de Oftalmologia Fundación Conde de Valenciana in order to collect information regarding complete ophthalmic examination, laboratory and cabinet tests, treatment, and disease progression.

Results: We included 11 patients with WG (18 eyes).

[Current immunologic and molecular data on the epidemiology of histoplasmosis in Morelos, Mexico].

The aim of the present paper was to analyze current data distribution of systemic mycosis, i.e. histoplasmosis, in the state of Morelos, Mexico.

Secondary glaucoma in patients with uveitis.

Purpose: To evaluate the prevalence of secondary glaucoma (SG), clinical forms of uveitis more frequently associated with glaucoma, and describe the treatment and complications encountered in a cohort of patients with glaucoma and uveitis during a 10-year period.

Methods: The hospital records of patients with uveitis referred to the Immunology Service of the Massachusetts Eye and Ear Infirmary for a decade were reviewed for cases of SG.

Results: One hundred and twenty of the 1,254 patients (9.

Outcomes in anterior uveitis associated with the HLA-B27 haplotype.

Objective: This study aimed to test the hypothesis that patients presenting with anterior uveitis who are HLA-B27 positive, either with or without associated systemic disease, have a less-favorable outcome than do patients with idiopathic anterior uveitis who are HLA-B27 negative.

Design: Retrospective case-controlled series.

Participants: Ninety-seven patients who were HLA-B27 positive with no systemic disease, 94 patients who were HLA-B27 positive with systemic disease, and 72 patients who were HLA-B27 negative who presented with anterior uveitis were studied.

Referral patterns of uveitis in a tertiary eye care center.

Objective: To analyze the referral patterns and diagnosis of uveitis during the past decade in a large tertiary eye center.

Design: The records of 1237 patients with uveitis referred to the Immunology Service of the Massachusetts Eye and Ear Infirmary from 1982 to 1992 were classified and analyzed. Data regarding sex, race, nationality, referral site, ages at presentation and onset of uveitis, ocular involvement, clinical characteristics, ocular condition, and systemic disease associations were obtained.

The value of combined serum angiotensin-converting enzyme and gallium scan in diagnosing ocular sarcoidosis.

Purpose: To evaluate the role of combined serum angiotensin-converting enzyme (ACE) activity and whole-body gallium (67GA) scanning in diagnosing sarcoidosis in patients with features consistent with ocular sarcoidosis but with normal or equivocal chest radiographs.

Methods: Serum ACE levels and whole-body 67GA scans were obtained as part of the initial workup in 22 patients with active ocular inflammation and ultimately biopsy-proven sarcoidosis (sarcoid uveitis group). A second group consisting of 70 patients with active uveitis in whom sarcoidosis also was considered a diagnostic possibility also was studied.

Systemic immunosuppressive therapy and the occurrence of malignancy in patients with ocular inflammatory disease.

Purpose: To compare the occurrence of malignancy in patients with severe ocular inflammatory disease treated with systemic corticosteroids alone or with systemic immunosuppressive drugs with or without systemic corticosteroids.

Methods: The clinical records of 543 patients with ocular inflammatory disease treated with systemic corticosteroids and/or immunosuppressive chemotherapy were reviewed in a retrospective cohort study. Characteristics of patients treated with corticosteroids alone were compared with characteristics of patients treated with immunosuppressive agents with or without preceding corticosteroid treatment.

T cell receptor V beta gene expression in experimental herpes stromal keratitis.

Our study examined T cell receptor (TCR) V beta mRNA expression in a murine model of experimental herpes simplex keratitis (HSK). We employed a polymerase chain reaction (PCR) technique to detect TCR V beta mRNA expression in the inoculated eyes of both HSK-susceptible and HSK-resistant mice at different time points after corneal inoculation with herpes simplex virus type 1 (HSV-1), followed by Southern blotting and densitometry analysis. In eyes from HSK-susceptible C.

Differential expression of alternatively spliced fibronectin in normal and wounded rat corneal stroma versus epithelium.

Purpose: The polymerase chain reaction was used to examine fibronectin (FN) expression during corneal scrape wounding with specific attention to the presence, absence, or gross changes of alternatively spliced FN as differentially expressed in the corneal stroma versus the epithelium in normal and wounded tissue.

Methods: Specific FN cDNA sequences were synthesized from rat cornea with total RNA and were amplified using various sets of synthetic oligonucleotide primers.

Results: The authors observed the presence and sustained the expression of total FN, EIIIA, EIIIB, and V-region FN mRNA in normal and injured corneal stroma for up to 3 weeks after scrape wounding.

Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis.

Purpose: To describe a series of patients with seronegative arthritic syndromes and HLA-B27-associated uveitis with severe, sight-threatening, posterior segment ocular manifestations.

Methods: The authors reviewed the records of 29 patients (17.4%) with posterior segment involvement from a cohort of 166 patients with HLA-B27-associated uveitis.

The syndrome of presumed ocular histoplasmosis in Mexico: a preliminary study.

A study to screen for the syndrome of presumed ocular histoplasmosis (SPOH) among native populations from three Mexican states was performed. Two of these states, Guerrero and Querétaro, were selected as histoplasmosis is endemic there, whereas Tlaxcala was considered a control, due to the absence of reported cases. A total of 253 individuals were submitted to ocular fundus examination to obtain evidence of SPOH.

Retrospective serological study of histoplasmosis in Mexico.

Mycotic immunodiagnosis was performed in 325 patients with clinical evidence of systemic mycoses, over a 5-year period, from different hospitals of Mexico City. Results showed 168 individuals that presented one positive serological test to Histoplasma capsulatum antigens. From these, only 27 patients were serologically positive to two or more tests, such as tube precipitin, immunodiffusion, complement fixation, and ELISA, and developed signs and symptoms of a histoplasmosis clinically classified as primary pulmonary.