Publications by authors named "Pedro Thyago Mozer Rodrigues"
Maternal 5CpG Imprints at the and Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues.
Graziela de Sá Machado Araújo Ronaldo da Silva Francisco Junior Cristina Dos Santos Ferreira Pedro Thyago Mozer Rodrigues Douglas Terra Machado
Front Genet
March 2018
Article Synopsis
- The study focuses on understanding how certain genes in mammals are regulated by differences in DNA methylation based on whether the gene is inherited from the mother or father, which leads to the creation of imprinted differentially methylated regions (iDMRs).
- Researchers identified 125 new candidate iDMRs that show patterns of methylation differing between parental alleles, particularly noting that some of these iDMRs are associated with specific tissues or developmental stages, influencing whether genes are turned on or off.
- Using RNA-Seq data, the study reveals that some genes' expressions near iDMRs can be regulated differently based on tissue type, suggesting that these distant iDMRs play a role in controlling how
The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent or independent of the parental origin of the nondisjoined chromosome 21. Linkage analysis is a standard method for the determination of the parental origin of this aneuploidy, although it is inadequate in cases with deficiency of samples from the progenitors.
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