Publications by authors named "Pedro Sanz Solana"
Article Synopsis
- The early development of lens opacities and lens subluxation significantly contribute to vision loss in patients with anterior megalophthalmos (AM), making cataract surgery more complex due to anatomical challenges.
- Postoperative complications commonly include intraocular lens dislocation, and patients with AM are also prone to a specific vitreoretinopathy that increases the risk of retinal detachment.
- The case study discusses a 36-year-old man with bilateral AM, previously misdiagnosed, who experienced vision loss due to lens subluxation and required both lens removal and vitrectomy to prevent retinal detachment, followed by implantation of an iris-claw lens.
Aims: To analyse myelination and outgrowth of the optic axons in relation to the neuro-ophthalmological manifestations of ethanol (EtOH) abuse during pregnancy.
Methods: An experimental model of chronic EtOH exposure was developed in rats and their offspring by subjecting the dams to a liquid diet (35% of the daily total calories as either EtOH or maltose-dextrose nutritional controls (Con). Eyeballs and optic nerves were obtained at key developmental stages and processed for morphologic, immunocytochemical and immunoblotting procedures, using alternatively antibodies against myelin basic protein (MBP) or neurofilament (NF) protein, and image analysing.
Clinical and experimental studies have highlighted the role played by thyroid hormones (TH) in neural and neuro-sensorial development. However, knowledge on TH mechanisms on the developing visual system is still incomplete. To uncover TH actions on the eyes and vision we carried out a microscopical study on the role of TH in the developing retina and optic nerve, in a rat model of controlled TH deficiency (THD).
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