Publications by authors named "Pedro Pereira Lira Furtado de Albuquerque"
Article Synopsis
- Hepaciviruses cause liver disease in horses, with three key viruses (NPHV, TDAV, EPgV) capable of chronic infections.
- This study aimed to model the NS5B polymerase (an enzyme crucial for viral RNA synthesis) of equine hepaciviruses and assess how well current drugs for hepatitis C (sofosbuvir and dasabuvir) interact with them.
- The results indicated that sofosbuvir could potentially be effective against equine pathogens, as the interactions of equine NS5B models with it were similar to those seen with HCV-NS5B, while interactions with dasabuvir showed less conservation.
Epidemiological investigation and analysis of the NS5B gene and protein variability of non-primate hepacivirus in several horse cohorts in Rio de Janeiro state, Brazil.
Andreza Soriano Figueiredo Elisabeth Lampe Pedro Pereira Lira Furtado de Albuquerque Flávia Löwen Levy Chalhoub Ana Maria Bispo de Filippis
Infect Genet Evol
April 2018
Among the hepacivirus species recently described, the non-primate hepacivirus/hepacivirus A found in horses and donkeys is closely related to the human hepatitis C virus (HCV). Therefore, the equine is an attractive surrogate large animal model for the study of HCV therapy, pathogenesis and prophylaxis. Despite global efforts, epidemiological and genetic studies have not elucidated the risk factors, virus distribution or genetic variability of the hepacivirus A, which are also important issues for the equine welfare.
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