Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients.

Aim: rs599839 polymorphism has been related with low levels of cholesterol and reduced coronary heart disease (CHD).

Methods: We investigated the frequency of this polymorphism in patients with heterozygous familial hypercholesterolemia (HeFH) in the Spanish familial hypercholesterolemia cohort, 230 with and 202 without CHD. Results & discussion: A lower G-allele prevalence was observed in HeFH patients with CHD with respect to controls, 35 versus 45%, respectively (p = 0.