Translation of Is Tightly Regulated by Upstream Open Reading Frames in Human Colorectal Cells.

ATP-binding cassette subfamily E member 1 (ABCE1) belongs to the ABC protein family of transporters; however, it does not behave as a drug transporter. Instead, ABCE1 actively participates in different stages of translation and is also associated with oncogenic functions. Ribosome profiling analysis in colorectal cancer cells has revealed a high ribosome occupancy in the human mRNA 5'-leader sequence, indicating the presence of translatable upstream open reading frames (uORFs).