Publications by authors named "Pedro Moral Moral"
Background: Common Variable Immunodeficiency (CVID) represents a heterogenic group of primary immunodeficiencies (PID) characterized by impaired antibody production and susceptibility to infections. Non-infectious complications, such as autoimmune diseases, lymphoproliferative disorders, and malignancies, now significantly impact prognosis. Moreover, both hematologic and solid organ malignancies are more frequently observed in CVID patients compared to other PIDs.
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- Common variable immunodeficiency (CVID) is characterized by low immunoglobulin levels and recurrent infections; up to 30% of patients experience granulomatous-lymphocytic interstitial lung disease (GLILD) as a non-infectious complication.
- A study analyzed the microbiomes of salivary, sputum, and fecal samples from CVID patients with GLILD and compared them to those without GLILD and healthy controls, revealing lower biodiversity in GLILD patients.
- The findings suggest significant alterations in the microbiome of GLILD patients that may be linked to both local and systemic immune dysregulation, highlighting a potential relationship between these microbiome changes and the disease.
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency characterized by decreased immunoglobulins and recurrent infections. Its aetiology remains unknown, and some patients present with severe non-infectious autoimmune or inflammatory complications with elevated associated morbimortality. Recently, intestinal dysbiosis has been proposed as a driver of immune dysregulation.
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- Common Variable Immunodeficiency (CVID) is a diverse group of primary immunodeficiency disorders that presents a wide range of clinical challenges, including significant non-infectious health issues among patients.
- A nationwide study in Spain over three years examined 250 CVID patients, revealing a diagnostic delay of about 10 years, with infectious complications initially predominant, though non-infectious lung diseases and immune disorders were more common overall.
- The study highlighted a high prevalence of associated conditions, such as benign lymphoproliferation and cancers, indicating a need for further research to develop better treatment strategies and improve the quality of life for those affected by CVID.
Integrating Clinics, Laboratory, and Imaging for the Diagnosis of Common Variable Immunodeficiency-Related Granulomatous-Lymphocytic Interstitial Lung Disease.
Front Immunol
May 2022
Background: Granulomatous-lymphocytic interstitial lung disease (GLILD) is a distinct clinic-radio-pathological interstitial lung disease (ILD) that develops in 9% to 30% of patients with common variable immunodeficiency (CVID). Often related to extrapulmonary dysimmune disorders, it is associated with long-term lung damage and poorer clinical outcomes. The aim of this study was to explore the potential use of the integration between clinical parameters, laboratory variables, and developed CT scan scoring systems to improve the diagnostic accuracy of non-invasive tools.
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- Primary immunodeficiency diseases (PID) are a group of over 400 genetic disorders that affect the immune system, leading to the need for immunoglobulin replacement therapy in patients.
- This study compares the costs of intravenous IG (IVIG) and subcutaneous IG (SCIG) treatments from the perspective of the Spanish National Healthcare System, focusing on both direct and indirect costs over one year.
- The findings indicate that SCIG is generally cheaper, saving about €4,266 annually per patient compared to IVIG, mainly due to lower drug and hospital administration costs, despite additional training costs for home infusion.
Prognostic Factors of Death in 151 Adults With Hemophagocytic Syndrome: Etiopathogenically Driven Analysis.
Mayo Clin Proc Innov Qual Outcomes
September 2018
Objective: To characterize the etiologies and clinical features at diagnosis of patients with hemophagocytic lymphohistiocytosis (HLH) and correlate these baseline features with survival using an etiopathogenically guided multivariable model.
Patients And Methods: The Spanish Group of Autoimmune Diseases HLH Study Group, formed in 2013, is aimed at collecting adult patients with HLH diagnosed in internal medicine departments between January 3, 2013, and October 28, 2017.
Results: The cohort consisted of 151 patients (91 men; mean age, 51.
Introduction: Malnutrition is a common health problem, especially in hospitalized patients, where it's associated with longer hospital stays and higher rates of morbidity and mortality. Furthermore, current scientific advances and life expectancy increase, have produced a progressive increase of mid- to long-term stay units (UMLE).
Aims: To determinate the prevalence of malnutrition on admission to a mid- to long-term stay unit, using MNA and VGS and to analyze the possible factors/clinical features associated with malnutrition and its consequences.