Publications by authors named "Pedro Miguel Martins"
Objective: Motivational interviewing (MI) is a client centered counseling approach which aims to promote behavior change by enhancing patient motivation through the exploration and resolution of ambivalence. This type of psychotherapy, initially designed for the treatment of substance use disorders (SUD), is now seen as an effective way to manage chronic physical and psychiatric diseases. Patients with Dual Diagnosis (DD), people who simultaneously have a SUD diagnosis and a mental illness, are a complex group of psychiatric patients who have a particularly low treatment engagement.
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- Biochemically unrelated macromolecules affect each other's functions through macromolecular crowding (MC) effects, which influence protein stability, structure, and kinetics.
- The study shows that lysozyme crystal solubility can predict how crowding agents impact its catalytic efficiency, highlighting the importance of enthalpic and entropic contributions from additives like sucrose and Ficoll-70.
- The findings suggest that proteins behave differently in crowded environments compared to when in dilute conditions, emphasizing the need for understanding these interactions to better comprehend cellular processes.