(Cucurbitaceae) Shows Strong Anti-Inflammatory Activity in Murine Models of Acute Inflammation.

is an endemic species from the semi-arid Brazilian, which has limited toxicological and pharmacological studies. This species belongs to a well-studied family known for its bioactive compounds used in treating inflammatory. This study aimed to identify secondary metabolites in the stems from , evaluate toxicity, and investigate the anti-inflammatory potential of the stem hydroalcoholic extract (SHE-Ag).

Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US.

Purpose: Persistent post-treatment genital hypoesthesia (PPTGH) is a primary symptom of post-SSRI sexual dysfunction (PSSD), an iatrogenic syndrome characterized by enduring sexual dysfunction following the discontinuation of some antidepressants. We aimed to estimate the frequency of PPTGH among past users of psychiatric treatments, particularly antidepressants.

Methods: We used a subsample of UnACoRN, a US/Canada survey of sexual and gender minority youth aged 15 to 29.

A novel and simple heat-based method eliminates the highly detrimental effect of xylene deparaffinization on acid-fast stains.

Objectives: Histopathology is an important method for diagnosing extrapulmonary tuberculosis, yet tissue sections are often negative for mycobacteria after use of acid-fast stain (AFS). This study investigated the mechanism of AFS use and the detrimental effect of histologic processing-in particular, xylene deparaffinization-on AFS and mycobacterial detection.

Methods: The target of the fluorescent Auramine O (AuO) AFS was investigated using triple staining with DNA- and RNA-specific dyes.

A simple heat-based alternative method for deparaffinization of histological sections significantly improves acid-fast staining results for Mycobacteria in tissue.

Histopathology is the study of how disease alters human and animal tissue and is based on the microscopic examination of stained tissue sections. To maintain tissue integrity, preserving it from degradation, it is initially fixed, primarily with formalin, before being treated with alcohol and organic solvents, allowing the infiltration of paraffin wax. The tissue can then be embedded in a mold and sectioned, usually at a thickness between 3 and 5 μm, before staining with dyes or antibodies to demonstrate specific components.

A competitive family to the Beta and Kumaraswamy generators: Properties, Regressions and Applications.

We define two new flexible families of continuous distributions to fit real data by compoun-ding the Marshall-Olkin class and the power series distribution. These families are very competitive to the popular beta and Kumaraswamy generators. Their densities have linear representations of exponentiated densities.

Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi's Sarcoma.

Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [, , or , , , , , , , , and ] that have the potential to induce malignant phenotypic characteristics of Kaposi's sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi's sarcoma.

The COVID-19 Pandemic in Brazil: Some Aspects and Tools.

The article presents some aspects related to the COVID-19 pandemic in Brazil including public health, challenges facing healthcare workers and adverse impacts on the country's economy. Its main contribution is the availability of two web applications for online monitoring of the evolution of the pandemic in Brazil and South America. The applications provide the possibility to download data in different formats, view interactive maps and graphs of the cumulative confirmed cases, deaths and lethality rates, in addition to presenting plots of moving averages for states and municipalities.

A Study of the Disruptive Effect of the Acetate Fraction of Extract on Biofilms.

Cryptococcosis, caused by yeasts of the genus , is an infectious disease with a worldwide distribution. and are the species that commonly cause this disease in humans; however, infections caused by , especially in immunocompromised patients, are increasingly being reported. Owing to the increase in the resistance of fungi to antifungals, and a lack of treatment options, it is important to seek new therapeutic alternatives such as natural products.

Covid-19 in Brazil: A sad scenario.

The main contribution of this article is to report general statistics about COVID-19 in Brazil, based on analysis of accumulated series of confirmed cases, deaths and lethality rates, in addition to presenting graphs of moving averages for states and municipalities. The data show that the pandemic in Brazil has grown rapidly since February 25th (date of the first reported case). Furthermore, the lethality rate of COVID-19 in Brazil is greater than in many other Latin American countries (Chile, Argentina, Uruguay and Paraguay).

The advertisement call of Boana freicanecae (Carnaval amp; Peixoto, 2004) (Anura: Hylidae), an endemic and poorly known treefrog from northeastern Brazil.

Boana freicanecae is a medium-sized hylid (males SVL= 37.3-42.2 mm) belonging to the B.

AdequacyModel: An R package for probability distributions and general purpose optimization.

Several lifetime distributions have played an important role to fit survival data. However, for some of these models, the computation of maximum likelihood estimators is quite difficult due to presence of flat regions in the search space, among other factors. Several well-known derivative-based optimization tools are unsuitable for obtaining such estimates.

A new class of lifetime models and the evaluation of the confidence intervals by double percentile bootstrap.

In this paper, we introduce a new three-parameter distribution by compounding the Nadarajah-Haghighi and geometric distributions, which can be interpreted as a truncated Marshall-Olkin extended Weibull. The compounding procedure is based on the work by Marshall and Olkin 1997. We prove that the new distribution can be obtained as a compound model with mixing exponential distribution.

Advertisement calls, intraspecific variation and species diagnosis of six Brazilian species of Elachistocleis (Anura: Microhylidae: Gastrophryninae).

We describe for the first time the advertisement calls of three Elachistocleis species (E. surumu, E. magna, E.

The Exponentiated Power Generalized Weibull: Properties and Applications.

We propose a new lifetime model called the exponentiated power generalized Weibull (EPGW) distribution, which is obtained from the exponentiated family applied to the power generalized Weibull (PGW) distribution. It can also be derived from a power transform on an exponentiated Nadarajah-Haghighi random variable. Since several structural properties of the PGW distribution have not been studied, they can be obtained from those of the EPGW distribution.