Limits of stability and falls during a multicomponent exercise program in faller older adults: A retrospective cohort study.

Background/objetives: Multicomponent exercise programs have been demonstrated to prevent falls in older adults. However, the underlying responsible mechanisms are not clear. We aimed to analyze the association between changes in the limits of stability (LOS) as a relevant balance component, and falls occurrence during a multicomponent physical exercise program.

Frailty, depression risk and 10-year hospitalization in older adults. The FRADEA study.

Objectives: To determine whether the interaction between frailty status and depression risk is associated with hospitalization density in older adults.

Methods: Ongoing cohort study in 794 subjects aged over 70 years from Albacete (Spain). Data were collected on depression risk, frailty, hospitalizations, and covariates.

Psychological and Functional Impact of COVID-19 in Long-Term Care Facilities: The COVID-A Study.

Objective: To analyze the psychological and functional sequelae of the COVID-19 pandemic among older adults living in long term care facilities (LTCFs).

Design: Cohort longitudinal study SETTING ANT PARTICIPANTS: A total of 215 residents ≥ 65 years without moderate-to-severe cognitive impairment, living in five LTCFs in Albacete (Spain).

Measurements: Baseline on-site data were collected between March - June 2020 and three-month follow-up between June to September 2020.

Immunogenicity after 6 months of BNT162b2 vaccination in frail or disabled nursing home residents: The COVID-A Study.

Background: There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2 in older adults in long-term care facilities (LTCFs) with frailty, disability, or cognitive impairment. We aimed to determine IgG antibody titer loss in older adults in LTCFs.

Methods: This is a multicenter longitudinal cohort study including 127 residents (90 females and 37 males) with a mean age of 82.

Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.

Background: Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia.

[Anemia and frailty in older adults from Spain. The FRADEA Study].

Introduction: The objective was to examine the prevalence of anemia according to the state of frailty and to analyze the relationship between anemia, hemoglobin concentration and frailty in a cohort of Spanish older adults.

Material And Methods: Cross-sectional substudy of the FRADEA (Frailty and Dependency in Albacete) cohort, a population-based concurrent cohort study conducted in people older than 69 years of Albacete (Spain). Of the 993 participants included in the first wave, 790 were selected with valid data on anemia and frailty.

Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.

Background/objectives: The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.

Design: Multicenter longitudinal cohort study.

The Functional Continuum Scale in Relation to Hospitalization Density in Older Adults: The FRADEA Study.

Background: There is a need to know the relationship between function and hospitalization risk in older adults. We aimed at investigating whether the Functional Continuum Scale (FCS), based on basic (BADL) and instrumental (IADL) activities of daily living and frailty, is associated with hospitalization density in older adults across 12 years of follow-up.

Methods: Cohort study, with a follow-up of 12 years.

COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn.

Background/objectives: To analyze mortality, costs, residents and personnel characteristics, in six long-term care facilities (LTCF) during the outbreak of COVID-19 in Spain.

Design: Epidemiological study.

Setting: Six open LTCFs in Albacete (Spain).

Frailty, depression risk, and 10-year mortality in older adults: the FRADEA study.

Objectives: To investigate if depression risk modifies the association between frailty and mortality in older adults.

Design: Ongoing cohort study.

Setting: Albacete city, Spain.

[Anemia increases mortality risk associated with frailty or disability in older adults. The FRADEA Study].

Objective: To analyze if anemia increases 10-year mortality risk associated to frailty and disability in older adults.

Design: Substudy of the FRADEA population-based concurrent cohort study (Frailty and dependence in Albacete), with a 10-year follow-up (2007-2017) in people older than 69years.

Setting: Albacete city, Spain.

Potential early biomarkers of sarcopenia among independent older adults.

Objectives: There are no tools or biomarkers for a quantitative analysis of sarcopenia.

Study Design: Cross-sectional study of the diagnosis of sarcopenia in 200 independent adults aged 70 years or over.

Main Outcome Measures: Sarcopenia was defined as loss of muscle mass together with low strength and/or loss of physical performance.

Associations of the antioxidant capacity and hemoglobin levels with functional physical performance of the upper and lower body limbs.

Herein we considered the role of oxidative stress on deficiencies of functional physical performance that could affect a future pre-frailty condition. Using principal component analyses (PCA), we created new variables to better describe the functionality regarding the physical performance of the upper and lower body limbs. Gait speed and the Short Physical Performance Battery (SPPB) score were classified by PCA to describe functional performance of the lower body limbs.

[Normal data of functional assessment tools of the elderly in Spain: the FRADEA study].

Objective: To determine the normal values of some of the functional assessment tools most used in Spain.

Design: Cross-sectional study of the first cut of a concurrent population based cohort.

Setting: Albacete city Health Area.

[Frailty and dependence in Albacete (FRADEA study): reasoning, design and methodology].

Objective: To obtain a cohort of subjects of equal to or greater than 70 years, representative of a Spanish urban population, to estimate the prevalence of frailty and follow it up over time to analyse associated factors.

Material And Methods: A prospective, population-based cohort study. From a population of 18,137 elderly persons, a representative sample of 1172 was randomly stratified, of which 993 (84.

[Primary pulmonary non-Hodgkin lymphoma with myocardial infiltration].

A case of primary pulmonary non-Hodgkin's lymphoma is presented. On this occasion, the lymphoma invaded the myocardium, an event which has not previously been reported in the literature. These neoplasms spread by proximity, and invasion of the pericardium, thoracic wall and oesophagus have been described.

Cardiovascular risk factors are associated with subclinical atherosclerosis in high functioning older adults.

Background: The prevalence of subclinical atherosclerosis and its relationship with cardiovascular risk factors (CVRFs) is not well known in high functioning older adults. These data can help to decide if the implementation of preventive measures is necessary in this population.

Objective: To determine the prevalence and progression of subclinical atherosclerosis in high functioning older adults, the relationship between subclinical atherosclerosis and CVRFs, and the influence of the CVRFs on subclinical atherosclerosis progression.

Differentiation between mild cognitive impairment and Alzheimer's disease using the FMLL mini-battery.

Aim: To construct and validate a mini-battery to discriminate between Alzheimer's disease (AD) and mild cognitive impairment (MCI) in patients seen at a hospital memory clinic.

Methods: In a cohort of 310 subjects (137 with MCI and 173 with AD), the area under the receiver operating curve (AUC) was used to select the neuropsychologic diagnostic test battery subtests with the best overall performance, namely, the Mini-Mental State Examination (MMSE, 0.715), Logical Memory II (LMII, 0.

[Neuropsychiatric symptoms in mild cognitive impairment and Alzheimer's disease].

Introduction: To describe the neuropsychiatric symptoms (NPS) in elderly patients with either mild cognitive impairment (MCI) or Alzheimer's disease (AD) and their relevance in the differential diagnosis between the two entities.

Material And Methods: A total of 179 subjects, aged more than 64 years old, with either MCI (n=90) or AD (n=89) and Global Deterioration Scale stage 4-5 were studied. NPS were assessed using the Neuropsychiatric Inventory scale.

[Elderly in an acute geriatric unit].

Although the implementation of acute geriatric units (AGUs) in general hospitals has a grade A of evidency, in Spain, only 12% of them have this resource. The estimation of geriatric especializad beds for the care of acute frail elderly people is of 2.6/1000 inhabitants older than 75 years.