Publications by authors named "Pedro Luis Martinez-Hernandez"
Introduction And Objectives: TPE drastically reduces serum triglyceride (sTG), but its role in the treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) or at risk of developing it, is not well established. The objectives were to assess the effectiveness and safety of TPE in the treatment of severe HTG (sHTG), as well as to evaluate the severity of HTG-AP treated with TPE.
Materials And Methods: Observational-retrospective-single-center study, in which a descriptive analysis of sHTG treated with TPE was conducted, with the aim of treating HTG-AP or preventing its recurrence.
Article Synopsis
- GPIHBP1 is crucial for lipoprotein lipase (LPL) function, which helps break down triglycerides in the bloodstream, and mutations in GPIHBP1 can lead to type I hyperlipoproteinemia.
- Two unrelated patients with severe hypertriglyceridemia and pancreatitis were studied, revealing very low LPL activity without LPL gene mutations or ApoCII deficiency.
- The study identified two new mutations in the GPIHBP1 gene in these patients, confirming its role in their severe hypertriglyceridemia.