Mitochondrial changes induced by trimetazidine in the myocardium.

Background: The aim was to assess the effect of trimetazidine (TMZ) on mitochondrial alterations induced in a canine model of brief, repeated episodes of ischemia.

Material/methods: Twelve crossbred dogs were analyzed, after double-blind randomization, to a 7-day treatment with either TMZ or placebo. Twenty brief, complete occlusions of the left anterior descending coronary artery were performed.

[Antithrombotic treatment in hypertensive patients with chronic atrial fibrillation. CARDIOTENS 99 study].

Background: Our main goals were to know the actual degree of oral anticoagulation and antiaggregation in hypertensive patients with atrial fibrillation in the daily clinical practice in Spain and to analyze any differences between primary care physicians and cardiologists.

Patients And Method: 32,051 outpatients attended the same day by 1,159 physicians (21% cardiologists) were prospectively included in a database taking into account a history of hypertension and atrial fibrillation, demographic data and ongoing treatments.

Results: Hypertension was detected in 10,555 patients and 999 of them had both hypertension and atrial fibrillation (9.