Small Molecule Inhibitors of Topoisomerase I Identified by Machine Learning and In Vitro Assays.

Tuberculosis (TB) caused by is a leading infectious cause of death globally. The treatment of patients becomes much more difficult for the increasingly common multi-drug resistant TB. Topoisomerase I is essential for the viability of and has been validated as a new target for the discovery of novel treatment against TB resistant to the currently available drugs.