Publications by authors named "Pedro I Hidalgo"
PR toxin is a well-known isoprenoid mycotoxin almost solely produced by Penicillium roqueforti after growth on food or animal feed. This mycotoxin has been described as the most toxic produced by this species. In this study, an in silico analysis allowed identifying for the first time a 22.
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- Mycophenolic acid (MPA) is produced by Penicillium species, and this study identified a 23.5-kb gene cluster in Penicillium roqueforti FM164 that is believed to be involved in MPA biosynthesis.
- The gene cluster contains seven genes similar to those found in Penicillium brevicompactum, with a focus on mpaC, a gene encoding a polyketide synthase, which was silenced to confirm its role in MPA production.
- Findings revealed a correlation between decreased MPA production and mpaC expression, along with a 174bp deletion in mpaC in strains that produce less MPA, indicating its significant
The PR-toxin is a potent mycotoxin produced by Penicillium roqueforti in moulded grains and grass silages and may contaminate blue-veined cheese. The PR-toxin derives from the 15 carbon atoms sesquiterpene aristolochene formed by the aristolochene synthase (encoded by ari1). We have cloned and sequenced a four gene cluster that includes the ari1 gene from P.
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