Publications by authors named "Pedro Henrique Nascimento de Aguiar"
Obesity and ancylostomiasis are considered public health problems. Recent studies have shown that infection by intestinal helminths in obese individuals can ameliorate metabolic disorder and improve glucose tolerance by decreasing both insulin resistance and low-intensity inflammation. However, few helminth species have been studied in this context, and some modulation mechanisms still require deeper investigation.
View Article and Find Full Text PDFAlbendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism.
Parasitol Res
March 2019
Article Synopsis
- Mass drug administration is a key factor in developing drug resistance in ruminant nematodes, with SNPs in the beta-tubulin gene linked to albendazole resistance.
- Despite the suspicion of similar resistance in hookworms, no strong evidence connects known SNPs to albendazole resistance in these parasites.
- A new albendazole-resistant Ancylostoma ceylanicum strain was created under drug pressure, but conventional resistance-associated SNPs were absent, suggesting different resistance mechanisms that warrant further investigation.
A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited.
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