Publications by authors named "Pedro H C Fischer"
Thermostabilizing mechanisms of canonical single amino acid substitutions at a GH1 β-glucosidase probed by multiple MD and computational approaches.
Rafael Eduardo Oliveira Rocha Diego César Batista Mariano Tiago Silva Almeida Leon Sulfierry CorrêaCosta Pedro Henrique Camargo Fischer
Proteins
February 2023
β-glucosidases play a pivotal role in second-generation biofuel (2G-biofuel) production. For this application, thermostable enzymes are essential due to the denaturing conditions on the bioreactors. Random amino acid substitutions have originated new thermostable β-glucosidases, but without a clear understanding of their molecular mechanisms.
View Article and Find Full Text PDFThe main-protease (M) catalyzes a crucial step for the SARS-CoV-2 life cycle. The recent SARS-CoV-2 presents the main protease (M) with 12 mutations compared to SARS-CoV (M). Recent studies point out that these subtle differences lead to mobility variances at the active site loops with functional implications.
View Article and Find Full Text PDFArticle Synopsis
- Protein-peptide interactions are crucial for many biological functions and are increasingly important in drug development due to their low toxicity and small interaction areas.
- A new database called Propedia has been launched, which contains over 19,000 high-resolution structures of protein-peptide complexes and allows users to analyze these interactions in detail.
- Propedia uses advanced clustering algorithms for better analysis of peptide similarities and has been shown to effectively predict peptides that can inhibit the SARS-CoV-2 main protease, demonstrating its practical utility in therapeutic research.