Ciprofol versus propofol for adult sedation in gastrointestinal endoscopic procedures: a systematic review and meta-analysis.

Introduction: Although propofol is widely preferred as a sedative agent in gastrointestinal endoscopy, its use is commonly associated with hemodynamic adverse events. New sedatives, such as ciprofol, are emerging with promising results. Thus, we aimed to perform a systematic review and meta-analysis to compare efficacy-, safety-, and satisfaction-related outcomes between ciprofol and propofol for adult sedation in gastrointestinal endoscopy.

Online Quality Control of Powder Bed Fusion with High-Resolution Eddy Current Testing Inductive Sensor Arrays.

This paper presents the development of a novel eddy current array (ECA) system for real-time, layer-by-layer quality control in powder bed fusion (PBF) additive manufacturing. The system is integrated into the recoater of a PBF machine to provide spatially resolved electrical conductivity imaging of the manufactured part. The system features an array of 40 inductive sensors spaced at 1 mm pitch and is capable of performing a full array readout every 0.

Indoor Content Delivery Solution for a Museum Based on BLE Beacons.

The digital transformation advancement enables multiple areas to provide modern services to their users. Culture is one of the areas that can benefit from these advances, more specifically museums, by presenting many benefits and the most emergent technologies to the visitors. This paper presents an indoor location system and content delivery solution, based on Bluetooth Low Energy Beacons, that enable visitors to walk freely inside the museum and receive augmented reality content based on the acquired position, which is done using the Received Signal Strength Indicator (RSSI).

Fecal microbiota transplantation and its repercussions in patients with melanoma refractory to anti-PD-1 therapy: scope review.

Introduction: despite being extremely effective in some cases, up to 70% of patients with melanoma do not respond to anti-PD-1/PD-L1 (primary resistance) and many of the responders eventually progress (secondary resistance). Extensive efforts are being made to overcome this resistance through new strategies, especially aimed at modulating the intestinal microbiota.

Objective: to assess whether fecal microbiota transplantation (FMT), associated with immunotherapy, is beneficial in the clinical course of patients with refractory melanoma.

Ocular severe involvement in oculofaciocardiodental syndrome: Description of a case series.

Background: Oculofaciocardiodental (OFCD) syndrome is a rare genetic disorder affecting ocular, facial, dental, and cardiac systems, being an X-linked condition caused by pathogenic variants in the BCL-6 corepressor gene (). We report a case series of three female patients with OFCD syndrome with severe glaucoma.

Results: Three female patients with OFCD syndrome with different variants involving gene, in heterozygosity: a seven-years-old girl with an insertion (c.

3'Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine.

Background: Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3'-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,2-trans-enoyl-CoA isomerase (TEI).

Methods: In this study CRISPR-Cas9 was used to either epitope tag or delete NUC1, NUC2, HLP and TEI, to investigate their role in miltefosine resistance mechanisms.

Demand Response Contextual Remuneration of Prosumers with Distributed Storage.

Prosumers are emerging in the power and energy market to provide load flexibility to smooth the use of distributed generation. The volatile behavior increases the production prediction complexity, and the demand side must take a step forward to participate in demand response events triggered by a community manager. If balance is achieved, the participants should be compensated for the discomfort caused.

A New Exergy Disaggregation Approach for Complexity Reduction and Dissipative Equipment Isolation in Thermoeconomics.

Thermoeconomics connects thermodynamic and economic concepts in order to provide information not available in conventional energy and economic analysis. Most thermoeconomicists agree that exergy is the most appropriate thermodynamic magnitude to associate with cost. In some applications, exergy disaggregation is required.

Dataset of an energy community's generation and consumption with appliance allocation.

Energy data measured on-site from buildings can help describe the consumption behavior of end-users and can be used to examine and prove certain theorems and models, that require a large volume of data to be gathered. However, the direct extraction of this data can often be a lengthily and costly process. As a result, a dataset of a residential community was constructed based on real data, where sample consumption and photovoltaic generation profiles were attributed to 50 residential households and a public building (municipal library), a total of 51 buildings.

Canine rabies in Belford Roxo City, Rio de Janeiro, Brazil: a case report.

Rabies is a highly lethal disease and is considered one of the most important zoonoses worldwide. In Brazil, the rabies cycle in domestic animals is under control. However, there is feedback from the wildlife cycle as many bats are present in the cities and rural areas of the country.

Towards circular economy in the textiles and clothing value chain through blockchain technology and IoT: A review.

The textile and clothing industry sector has today a big environmental impact, not only due to the consumption of water and the use of toxic chemicals but also due to the increasing levels of textile waste. One way to reduce the problem is to circularise the, currently linear, textile and clothing value chain, by using discarded clothes as raw material for the production of new clothes, transforming it into a model of circular economy. This way, while reducing the need to produce new raw materials (e.

Recruiting strategic human capital from MNCs-Does hiring MNC managers enable exporting in domestic firms?

Exporting is a central growth strategy for most firms and managers with international experience are instrumental for export decisions. We suggest that such managers can be hired from Multinational Corporations (MNCs). We integrate theory from strategic human capital research into models explaining export decisions.

The Hummingbird Collection of the Natural History and Science Museum of the University of Porto (MHNC-UP), Portugal.

Background: The Hummingbird (Family Trochilidae) Collection of the Natural History and Science Museum of the University of Porto (MHNC-UP) is one of the oldest collections of this family harboured in European museums. Almost 2,000 specimens, that encompass most of the taxonomic diversity of this family, were collected in the late 19 Century. The collection is relevant due its antiquity and because all specimens were bought from the same provider, mainly as mounted specimens, for a Portuguese private collection of Neotropical fauna.

Fundamental privacy rights in a pandemic state.

Faced with the emergence of the Covid-19 pandemic, and to better understand and contain the disease's spread, health organisations increased the collaboration with other organisations sharing health data with data scientists and researchers. Data analysis assists such organisations in providing information that could help in decision-making processes. For this purpose, both national and regional health authorities provided health data for further processing and analysis.

MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal.

Introduction: Primary open-angle glaucoma is the most frequent subtype of glaucoma. Relatives of primary open-angle glaucoma patients have an increased risk of developing the disease, suggesting a genetic predisposition to the disease. MYOC was the first primary open-angle glaucoma-causing gene identified.

Use of Sensors and Analyzers Data for Load Forecasting: A Two Stage Approach.

The increase in sensors in buildings and home automation bring potential information to improve buildings' energy management. One promissory field is load forecasting, where the inclusion of other sensors' data in addition to load consumption may improve the forecasting results. However, an adequate selection of sensor parameters to use as input to the load forecasting should be done.

Unexplained Visual Loss After Silicone Oil Removal: A 7-Year Retrospective Study.

Introduction: Unexplained visual loss after removal of silicone oil from the eye has been described. The purpose of this study is to determine the incidence of unexplained loss of visual acuity after SO removal and to provide possible explanations for this phenomenon.

Methods: This retrospective study included patients that underwent vitreoretinal surgery, at Centro Hospitalar São João, between January of 2012 and October of 2018.

Consumption Optimization in an Office Building Considering Flexible Loads and User Comfort.

This paper presents a multiperiod optimization algorithm that is implemented in a Supervisory Control and Data Acquisition system. The algorithm controls lights and air conditioners as flexible loads to reduce the consumption and controls a dishwasher as a deferrable load to implement the load shifting. Several parameters are considered to implement the algorithm for several successive periods in a real building operation.

Adenosinergic signalling in chondrogenesis and cartilage homeostasis: Friend or foe?

Chondrocytes and their mesenchymal cell progenitors secrete a variety of bioactive molecules, including adenine nucleotides and nucleosides, but these molecules are not usually highlighted in review papers about the secretome of these cells. Ageing and inflammatory insults compromise chondrocytes ability to keep ATP/adenosine synthesis, release and turnover. Cartilage homeostasis depends on extracellular adenosine levels, which acting via four P1 purinoceptor subtypes modulates the release of pro-inflammatory mediators, including NO, PGE and several cytokines.

Influence of breed on the clinical and hemato-biochemical parameters in sheep experimentally infected with sp.

Early diagnosis of leptospirosis may aid in a favorable prognosis in infected animals, but there are few reports of clinical and hematochemical changes in the ovine species, nor whether the breed exerts any influence on the response to infection. Thus, the objective of the present study was to evaluate the clinical, biochemical and hematological alterations in Santa Inês and crossbred ewes challenged with serogroup Pomona serovar Kennewicki. Twenty-four sheep were used in this experiment, 12 crossbred (group A) and 12 Santa Inês (group B).

Drug policy and Collective Health: necessary dialogues.

The current status of policies on illicit drugs has implications for Collective Health that need to be discussed in depth. This essay aims to explore, in light of the best evidence, the public health impact of drug policies focused on the criminalization of growing, selling, and consuming psychoactive substances. Brazil provides the context for the main analysis.

[Femicides in the city of Campinas, São Paulo, Brazil].

Femicide is the intentional killing of a woman or girl on account of her gender. The term allows differentiating crimes of gender violence from murders of women in other circumstances. The aim of this study is to characterize femicides, sometimes called feminicides, that occurred in 2015 in Campinas, São Paulo State, Brazil.

Shape responses in a macaque frontal area connected to posterior parietal cortex.

The primate dorsal visual stream processes object shape to guide actions involving an object, but the transmission of shape information beyond posterior parietal cortex remains largely unknown. To clarify the information flow between parietal and frontal cortex, we applied electrical microstimulation during functional Magnetic Resonance Imaging (fMRI) in a shape-selective patch in the posterior part of the Anterior Intraparietal area (pAIP) to chart its connectivity. Subsequently, we recorded single-unit responses to images of objects in the fMRI activation in prefrontal cortex, corresponding to area 45B, elicited by pAIP microstimulation.

Frailty Syndrome in Association with Depressive Symptoms and Functional Disability among Hospitalized Elderly.

We sought to examine the frailty association with depression and functional disability in hospitalized older adults. In particular, we compared non-frail, pre-frail, and frail elderly hospitalized individuals. We performed a cross-sectional study with 255 hospitalized Brazilian elderly patients.