Publications by authors named "Pedro F S Palma"
Stanniocalcin 1 (STC1) and parathyroid hormone-related protein (PTHrP) are calciotropic hormones in vertebrates. Here, a recently hypothesized metabolic role for these hormones is tested on European sea bass treated with: (i) teleost PTHrP(1-34), (ii) PTHrP(1-34) and anti-STC1 serum (pro-PTHrP groups), (iii) a PTHrP antagonist PTHrP(7-34) or (iv) PTHrP(7-34) and STC1 (pro-STC1 groups). Livers were analysed using untargeted metabolic profiling based on proton nuclear magnetic resonance (H-NMR) spectroscopy.
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- In fishes, including ancient jawless lampreys, glucose regulation is less strict compared to mammals, with variations in plasma glucose levels.
- The glucagon-like family of peptides, responsible for glucose and lipid regulation, has evolved differently in fishes, retaining additional gene members not found in mammals.
- The study focused on the European sea bass's glucagon-like gene expression, revealing early evolution of these receptors and peptides during vertebrate development, with distinct functions likely adapted over time.