Natural history and clinical characteristics of 50 patients with Wolfram syndrome.

Purpose: To describe clinical characteristics of diabetes mellitus (DM) in a group of patients with Wolfram Syndrome (WS).

Methods: Descriptive, cross-sectional observational design. The sample consisted of 50 patients diagnosed with WS.

[Long QT syndrome and polymorphic ventricular tachycardia due to hypopituitarism. Report of one case].

Symptoms of hypopituitarism are usually chronic and nonspecific, but rarely the disease can have acute and life threatening manifestations. We report a 53 years old female with a pituitary adenoma that was admitted to our hospital because of syncope. The electrocardiogram showed sinus bradycardia with a prolonged QT interval.

[Predictive factors of hypertension in patients with diagnostic doubts of persistent hypertension].

Background: White coat hypertension (WCH) is a prevalent clinical situation which requires a therapeutic management different from persistent hypertension (PH). To distinguish between patients with WCH and uncertain hypertension from patients with PH, an ambulatory blood pressure monitoring (ABPM) is usually indicated, yet it is not available in primary care. Thereby, predictors of WCH on the basis of pre-test (pre-ABPM) clinical characteristics have been suggested.