[Evaluation of the Dunning Kruger effect in relation to vaccination: a study of messages on the social network LinkedIn.].

Objective: The Dunning-Kruger effect refers to an excess of confidence regarding one's abilities and knowledge; trust leads to transmitting information in an assertive manner, regardless of its validity or veracity, of experts, but of great impact on public opinion. This study evaluated the existence of the Dunning-Kruger effect in messages related to vaccination against COVID-19 on LinkedIn.

Methods: 448 messages were evaluated and the authors' knowledge and training on the subject were related.

Combined Alzheimer's disease and cerebrovascular staging explains advanced dementia cognition.

Introduction: The absence of a consensus system for full neuropathological evaluation limits clinicopathological studies and comparability between laboratories. Combined staging for Alzheimer's type and cerebral vascular pathology may allow a better classification of cases for clinical and cognitive correlation.

Methods: Cognitive and postmortem neuropathological data were obtained from 70 brains donated to the Tissue Bank of the Centro de Investigación de Enfermedades Neurológicas (CIEN) Foundation according to recently developed staging schemes for Alzheimer's type and vascular pathology.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel C82R mutation in the NOTCH3 gene.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited cerebrovascular disease associated with mutations in the NOTCH3 gene on chromosome 19, and represents the most common hereditary stroke disorder. We describe a pedigree, which suffered the classical clinical CADASIL pattern of migraine headaches, recurrent subcortical infarcts, and subcortical dementia, associated with a previously undescribed missense mutation (c.[244T>C], p.

[New antiepileptic drugs and neuropathic pain. From molecular medicine to clinical practice].

Neuropathic pain is a phenomenon characterized by a high prevalence in population that may be originated by very different etiologies. In contrast to nociceptive pain, painful signal is originated in the nervous system, it presents poor responses to conventional treatments and may worsen the quality of life. Antiepileptic drugs have demonstrated its effectiveness in the treatment of this pathology, and owing to the important development of these drugs in the last years, they may become a very effective tool.