Prognostic impact of nectin-like molecule-5 (CD155) expression in non-small cell lung cancer.

Background: CD155 is a transmembrane protein that inhibits antitumor immune response and represents a predictor of worse prognosis in non-small-cell lung cancer (NSCLC). However, it remains unexplored its association with clinical characteristics and genomic status of Latin American patients. This study characterizes the CD155 expression and its clinical implications in this population.

Risk Factors Associated with Musculoskeletal Injuries within the Crew of the Leopard 2 A6 Main Battle Tank Using Inertial Movement Unit Sensors: A Pilot Study.

This study aims to assess the musculoskeletal risk of military personnel on a Leopard 2 A6 main battle tank crew and to identify associated factors for future prevention and mitigation strategies. A sample of 57 Portuguese military personnel, who are or were part of the Leopard 2 A6 main battle tank crew, answered a questionnaire on their perception of task performance, considering muscle demands, comfort, posture, movements, and associated symptoms. A subsample of four soldiers from the Armoured Squadron of the Portuguese Mechanized Brigade were assessed using an inertial measurement unit system and underwent a whole-body kinematic analysis coupled with a Rapid Entire Body Assessment during a simulated two-hour mission.

Longitudinal analysis of echocardiographic and cardiac biomarker variables in dogs with atrial fibrillation: The optimal rate control in dogs with atrial fibrillation II study.

Background: Rate control (RC; meanHR ≤ 125 bpm) increases survival in dogs with atrial fibrillation (AF). The mechanisms remain unclear.

Hypothesis/objectives: Investigate echocardiographic and biomarker differences between RC and non-RC (NRC) dogs.

Congenital right atrial diverticulum in a kitten.

A four-month-old domestic shorthair cat with no clinical signs was referred for further examination of a heart murmur. An echocardiogram revealed marked right atrial dilation, extending into the left hemithorax. Computed tomography angiography was conducted to investigate further, which revealed a balloon-shaped, contrast-filled cavity on the cranial and left side of the chest that connected to the right atrium through a narrow passage.

Double-Outlet Right Atrium in a Young Cat.

• DORA is a rare variant of endocardial cushion defect reported in both people and cats. • DORA is associated with variable clinical presentation and prognosis. • DORA is a possible differential diagnosis in cats with ASD and obstruction to LA outflow.

Clinical presentation, management, and survival in dogs with persistent atrial standstill in the United Kingdom.

Objectives: To investigate the clinical and echocardiographic presentation of dogs with persistent atrial standstill (PAS), identify variables measured at first presentation that could predict their survival, and document the progression of the disease after pacing.

Materials And Methods: Retrospective study of medical records of dogs diagnosed with PAS at three referral hospitals of the United Kingdom over seven years.

Results: Twenty-six dogs were diagnosed with PAS during the study period.

Flight muscle size reductions and functional changes following long-distance flight under variable humidity conditions in a migratory warbler.

Bird flight muscle can lose as much as 20% of its mass during a migratory flight due to protein catabolism, and catabolism can be further exacerbated under dehydrating conditions. However, the functional consequences of exercise and environment induced protein catabolism on muscle has not been examined. We hypothesized that prolonged flight would cause a decline in muscle mass, aerobic capacity, and contractile performance.

A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.

Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized our understanding of heterogeneity, in isolation they cannot correlate phenotypic information within a physiologically relevant live-cell state with molecular profiles. This inability to integrate a live-cell phenotype-such as invasiveness, cell:cell interactions, and changes in spatial positioning-with multi-omic data creates a gap in understanding cellular heterogeneity.

Prophylactic use of a lidocaine constant rate infusion versus saline in dogs undergoing balloon valvuloplasty for management of pulmonic stenosis: A randomized control trial.

Objective: To evaluate the effect of a prophylactic lidocaine constant rate infusion (CRI) on the incidence and malignancy of catheter-induced ventricular ectopic complexes (VECs) during balloon valvuloplasty for management of pulmonic stenosis in dogs.

Study Design: Single-centre, prospective, randomized study.

Animals: Client-owned dogs (n = 70) with pulmonic stenosis.

Optimal rate control in dogs with atrial fibrillation-ORCA study-Multicenter prospective observational study: Prognostic impact and predictors of rate control.

Background: The optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation.

Hypothesis/objectives: Dogs with a 24 hours Holter-derived meanHR ≤125 beats per minute (bpm; rate controlled) survive longer than dogs with higher meanHR.

Movement Prototypes in a Complex Teamgym Gymnastics Technique on the Vaulting Table and Their Relationship with Judges' Scores.

A successful high-level gymnastics performance is the result of the coordination and inter-relation of body segments to produce movement prototypes. In this context, the exploration of different movement prototypes, as well as their relations with judges' scores, can aid coaches to design better learning and practice methodologies. Therefore, we investigate if there are different movement prototypes of the technique of the handspring tucked somersault with a half twist (HTB) on a mini trampoline with a vaulting table and its relations with judges' scores.

A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.

Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, hybridization, and flow cytometry. While these approaches have revolutionized our understanding of heterogeneity, in isolation they cannot correlate phenotypic information within a physiologically relevant live-cell state, with molecular profiles. This inability to integrate a historical live-cell phenotype, such as invasiveness, cell:cell interactions, and changes in spatial positioning, with multi-omic data, creates a gap in understanding cellular heterogeneity.

Evaluation of nutritional status and adherence to dietary monitoring among patients with human T-cell leukemia virus type 1 infection.

Background & Aims: The nutritional status of people infected with Human T-Cell Leukemia Virus type 1 (HTLV-1) is rarely studied. Malnutrition affects the immune system, but the consequences of this remain unknown in HTLV-1 infection. This study aimed to analyze the nutritional status, food intake, and ability to adhere to dietary counseling in people with symptomatic HTLV-1 infection.

Interruptions during general practice consultations: negative impact on physicians, and patients' indifference.

Background: Interruptions can impact consultation duration, doctors and patients' satisfaction, and quality of care provided. Although most of them seem to have a negative impact, affecting doctor-patient relationship and interfering with clinical reasoning, which increases the risk of error, there is still no evidence on their global impact on consultations.

Objectives: To evaluate the number and duration of interruptions during general practice consultations.

Outcome clinical audit: analyses of interventional closure of patent ductus arteriosus in dogs.

Objectives: The objectives of this study were to determine whether conducting a clinical audit was achievable in a group of centres that perform interventional cardiac procedures and to report the success and complications rates in dogs diagnosed with patent ductus arteriosus.

Methods: This was a multicentre, European-wide, prospective study. Patient data were entered into a bespoke database prior to commencing interventional closure of patent ductus arteriosus in all animals undergoing this procedure during the study period.

Peri-Traumatic Dissociation and Tonic Immobility as Severity Predictors of Posttraumatic Stress Disorder After Rape.

Some individuals show abnormal reactions to extreme fear and life-threatening situations, including tonic immobility (TI) and peri-traumatic dissociation (PTD). We aimed to investigate the association of TI and PTD with posttraumatic stress disorder (PTSD) in women who experienced sexual violence and the risk factors for PTD occurrence. We compared PTSD severity in 86 young adult women with PTSD after a sexual violence exposure grouped according to the presence of PTD and TI.

Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury.

Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte injury, acute kidney injury affects renal tubular epithelial cells. Despite these differences, a cardinal feature of both acute and chronic kidney diseases is dysregulated actin cytoskeleton.

Evaluation of Upper Limb Joint Contribution to Racket Head Speed in Elite Tennis Players Using IMU Sensors: Comparison between the Cross-Court and Inside-Out Attacking Forehand Drive.

This study aimed to quantify and compare the upper limb angular kinematics and its contributions to the racket head speed between the cross-court (CC) and inside-out (IO) attacking tennis forehand of elite tennis players in a competitive environment. A new approach was used to study the forehand drive with mini-inertial sensors of motion capture to record the kinematic data. Six strokes in each direction per participant (72 shots in total) were chosen for analysis.

Computed tomography diagnosis of a caval-azygos communication in a dog with cor triatriatum dexter.

An 18-month-old Springer Spaniel was presented for investigation of ascites, exercise intolerance and suspected cor triatriatum dexter. Division of the right atrium into two separate chambers by an anomalous perforated membrane consistent with cor triatriatum dexter was confirmed during echocardiography. However, a routine agitated saline contrast (bubble) study yielded results that could not be explained by the congenital heart defect alone.

Concurrent validity of an inertial measurement system in tennis forehand drive.

The kinematic analysis in tennis forehand drive is crucial to understand the quality of this technique. The inertial measurement units (IMUs) due to its portability, occlusion free, larger capturing area and faster set up preparation, present an alternative to the optical motion capture systems (OS) considered a reference criterion system, however the degree of accuracy is task specific. This study aimed to compare the concurrent validity of a IMUs (Xsens MVN system) with an OS (Qualisys AB) for measuring upper and lower limb kinematics.

Low plasma taurine levels in English cocker spaniels diagnosed with dilated cardiomyopathy.

Objectives: The aims of this study were to evaluate taurine levels in English cocker spaniels with dilated cardiomyopathy and assess their survival time and natural progression of their disease.

Materials And Methods: Retrospective comparison of English cocker spaniels with dilated cardiomyopathy phenotype with and without taurine deficiency at the cardiology department of a UK academic referral centre between 2008 and 2018.

Results: Taurine plasma concentration was available in 16 English cocker spaniels with dilated cardiomyopathy phenotype; 13 of 16 had congestive heart failure and three of 16 did not.

Analytical Model for Blood Glucose Detection Using Electrical Impedance Spectroscopy.

Pathogens and adulterants in human feeding consumables can be readily identified according to their electrical properties. Electrical bioimpedance analysis (BIA) has been widely used for body contents characterization, such as blood, urine, lactate, and sweat. If the concentration of glucose in blood alters the electrical properties of the blood medium, then the impedance spectrum obtained by BIA can be used to measure glycemia.

Diagnosis and management of canine atrial fibrillation.

Atrial fibrillation (AF) is the most common non-physiological arrhythmia in dogs and humans. Its high prevalence in both species and the impact it has on survival time and quality of life of affected patients, makes it a very relevant topic for medical research. In dogs, the diagnosis of AF is usually fairly straightforward, but optimal management can be complicated.