Publications by authors named "Pedro Arend Guazzelli"
Front Mol Neurosci
January 2020
Article Synopsis
- Acute liver failure (ALF) leads to rapid liver dysfunction, causing issues like hepatic encephalopathy (HE), which is influenced by brain changes such as astrocyte dysfunction and energy metabolism problems.
- A study on rats showed that those with ALF had higher ammonia and lactate levels and exhibited significant signs of astrocytic reactivity and alterations in brain energy metabolism.
- Findings indicated that early-stage ALF results in a hypermetabolic brain state, increased oxidative stress, and heightened astrocytic activity, partly due to elevated mitochondrial oxidation of glutamate.
