Publications by authors named "Pedro Adolpho de Menezes Pacheco Serio"
Article Synopsis
- - The study explored the presence of pathogenic germline variants in Brazilian patients with pancreatic adenocarcinoma, involving 192 unselected patients and analyzing 113 cancer-related genes, revealing a median age of 61 years and a significant portion presenting advanced disease stages.
- - Of the patients, 6.25% carried pathogenic variants linked to known pancreatic cancer genes, while 13% had variants in genes with less established associations, with CHEK2, ATM, and FANC being the most affected.
- - No differences in the prevalence of these variants were found based on family cancer history or ancestry, suggesting that all Brazilian pancreatic cancer patients should undergo genetic testing regardless of their background.
Objectives: To identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants.
Methods: A customized gene panel was assembled based on data from previous sequencing studies of breast cancer from young women. Triple-negative and luminal tumors and paired blood samples from young breast cancer patients were sequenced, and identified gene variants were searched for their driver potential, in databases and literature.
Somatic Mutational Profile of High-Grade Serous Ovarian Carcinoma and Triple-Negative Breast Carcinoma in Young and Elderly Patients: Similarities and Divergences.
Cells
December 2021
Background: Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that share similarities; however, different ages of onset may reflect distinct tumor behaviors. Thus, our aim was to compare somatic mutations in potential driver genes in 109 TNBC and 81 HGSOC from young (Y ≤ 40 years) and elderly (E ≥ 75 years) patients.
Methods: Open access mutational data (WGS or WES) were collected for TNBC and HGSOC patients.
Stromal Cell Signature Associated with Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer.
Cells
December 2019
Breast cancer stromal compartment, may influence responsiveness to chemotherapy. Our aim was to detect a stromal cell signature (using a direct approach of microdissected stromal cells) associated with response to neoadjuvant chemotherapy (neoCT) in locally advanced breast cancer (LABC). The tumor samples were collected from 44 patients with LABC (29 estrogen receptor (ER) positive and 15 ER negative) before the start of any treatment.
View Article and Find Full Text PDFBreast cancer arising in very young patients may be biologically distinct; however, these tumors have been less well studied. We characterized a group of very young patients (≤ 35 years) for BRCA germline mutation and for somatic mutations in luminal ( negative) breast cancer. Thirteen of 79 unselected very young patients were 1/2 germline mutation carriers.
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