Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling.

Hydrogen peroxide (HO) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors. However, these redox targets are orders of magnitude less HO-reactive and abundant than cytoplasmic peroxiredoxins.

[Cutaneous leishmaniasis. Unusual disease in Portugal?].

Due to its morbility and disfiguring scars, cutaneous leishmaniasis is a serious Public Health problem. The incidence of the disease, world wide, is estimated to be of 1 million to 1.5 million cases per year.