Unveiling the evolution of policies for enhancing protein structure predictions: A comprehensive analysis.

Predicting protein structure is both fascinating and formidable, playing a crucial role in structure-based drug discovery and unraveling diseases with elusive origins. The Critical Assessment of Protein Structure Prediction (CASP) serves as a biannual battleground where global scientists converge to untangle the intricate relationships within amino acid chains. Two primary methods, Template-Based Modeling (TBM) and Template-Free (TF) strategies, dominate protein structure prediction.