Platelet Count and IgE Level in Chronic Idiopathic Urticaria: A Case-control Study.

Background And Aim: Chronic Urticaria is an allergic disorder that affects about 0.5 to 5% of the population in different communities. The disease's chronic course and long-term onset impose high economic and psychological costs on communities, adversely affecting individual and social life.

The Prevalence of Asthma among Iranian Children and Adolescent: A Systematic Review and Meta-Analysis.

Background: Asthma is an important reason for hospitalization in children aged under five years. Information about the current status of asthma in Iranian children can help the Iranian health sector plan carefully and prevent asthma incidence by educating the families. The present systematic review and meta-analysis is aimed at estimating asthma prevalence in Iranian children and adolescents.

Diarrhea as a Presenting Symptom of Coronavirus Disease 2019 in Children.

Gastroenteritis is common among children and is usually caused by bacterial, viral, or parasitic gastrointestinal infections. The occurrence of gastroenteritis as the only symptom of coronavirus disease 2019 (COVID-19) is an uncommon condition. We present a 16-month-old girl that has recently been admitted to our hospital with vomiting, diarrhea, and lethargy, who was ultimately diagnosed with COVID-19.

Hepatic Failure following Metronidazole in Children with Cockayne Syndrome.

Cockayne syndrome is an uncommon autosomal recessive disease characterized by microcephaly, abnormal growth, and pathologic premature aging. The purpose of this report is to evaluate liver failure in children with Cockayne syndrome following metronidazole administration. The first case was a 2-year-old boy with Cockayne syndrome.

Serum level of stem cell factor and its soluble receptor in aspirin-exacerbated respiratory disease.

Stem cell factor (SCF) may be associated with inflammatory processes leading to aspirin-induced asthma. This study evaluated the relationship between serum level of SCF and its soluble receptor with aspirin-induced asthma. Twenty-five patients and 25 healthy controls were enrolled in this study.

The relationship between B7 homologous 1 with interleukin-4, interleukin-17 and interferon gamma in patients with allergic rhinitis.

: The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship between cytokines and PD-L1. : In this experimental study, 80 patients with allergic rhinitis were enrolled according to inclusion and exclusion criteria.

The Prevalence of Allergic Rhinitis among Iranian Children: A Systematic Review and Meta-Analysis.

Background: The prevalence of allergic rhinitis in the world is 10-15%, and it is currently the most common chronic disease among children. There is no comprehensive statistics about the prevalence of allergic rhinitis among Iranian children, therefore, this systematic review and metaanalysis was conducted to evaluate the prevalence of allergic rhinitis among the Iranian children.

Methods: The present study was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

The chemokine CCL28 is elevated in the serum of patients with celiac disease and decreased after treatment.

Accumulating evidence show that many inflammatory cytokines are involved in pathophysiology of celiac disease (CD). CCL28 known as mucosa associate epithelial chemokine (MEC) is produced by mucosa and chemoattracts IgA-producing B cells into the mucosa. However, its levels in patients with CD have not yet been elucidated.

Inverse correlation of soluble programmed cell death-1 ligand-1 (sPD-L1) with eosinophil count and clinical severity in allergic rhinitis patients.

Background: T-cell response outcome is determined by co-stimulatory/inhibitory signals. Programmed cell death-1 ligand-1 (PD-L1) is a member of these co-signaling molecules with known soluble form in human serum. Soluble PD-L1 (sPD-L1) is also recognized in patients with some types of malignancy or autoimmune disorders, though there are few studies on sPD-L1 roles in allergic diseases.

Breastfeeding and Helicobacter pylori Infection in Early Childhood: a Continuing Dilemma.

Objective: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans. Chronic colonization increases the risk of duodenal ulcer and gastric cancer.

A model-based approach to stability analysis of autonomic-cardiac regulation.

This paper presents a model-based approach to analyze the stability of autonomic-cardiac regulation. In the proposed approach, a low-order lumped parameter model of autonomic-cardiac regulation is used to derive the system equilibria based on the measurements of heart rate and blood pressure, and then the stability margin associated with the equilibria is quantified via the Lyapunov's stability analysis method. A unique strength of the proposed approach is that it provides a quantitative measure of autonomic-cardiac stability via a computationally efficient analysis.

Effect of supplementary zinc on body mass index, pulmonary function and hospitalization in children with cystic fibrosis.

Zinc deficiency, which is common in patients with cystic fibrosis (CF), can lead to several complications that may increase the number of hospital admissions in this group of patients. As supplementary zinc can prevent such complications, this study was performed to evaluate the effect of supplementary zinc on body mass index (BMI), forced expiratory volume in one second (FEV1) and number of hospitalizations in CF patients. In this study, 30 children with CF, who were referred to the Digestive Diseases Clinic of the Children's Medical Center in Tehran, were enrolled.

Noninvasive subject-specific monitoring of autonomic-cardiac regulation.

This paper presents a feasibility study of a model-based approach to noninvasive and subject-specific monitoring of autonomic-cardiac regulation. The proposed approach is built upon individualizing a physiologically-based model by applying a parameter estimation method to routine clinical observations, thereby assuring physical transparency, computational efficiency, and clinical adaptability. To develop an efficient parameter estimation procedure, a parametric sensitivity analysis was performed on the autonomic-cardiac regulation model to identify high-sensitivity model parameters whose changes exert significant impacts on the system outputs.

A novel approach to the design of an artificial bionic baroreflex.

This paper presents a computationally efficient method to design an artificial bionic baroreflex. This work is built upon a physiology-based mathematical model of autonomic-cardiac regulation describing the regulation of heart rate and blood pressure as well as a system identification technique to identify a subject-specific mathematical model for each subject. The control strategy to regulate blood pressure is developed based upon the in-vivo baroreflex mechanism.

Autonomic-cardiorespiratory regulation: a physiology-based mathematical model.

This paper presents a novel physiology-based mathematical model of autonomic-cardiorespiratory regulation described by a set of three nonlinear, coupled differential equations. We improved our previously proposed autonomic-cardiac regulation model by considering neuromechanical and mechanical coupling of cardiovascular and respiration systems including lung stretch-receptor reflex and venous return variation. We also introduced a differential equation describing respiration rate regulation which mainly originates in the medullary respiratory center.

A systematic approach to local stability analysis of cardiovascular baroreflex.

This paper presents a novel systematic approach to the stability analysis of the cardiovascular (CV) baroreflex. The proposed approach determines the equilibrium state and the system stability in its neighbourhood with computational efficiency, once the parameters of the CV baroreflex model are specified for an individual. We first propose a linearization-based analytical method for determining the equilibrium state of the CV baroreflex.

Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease.

Background/aims: Gastroesophageal reflux disease (GERD) and cow's milk allergy (CMA) are two common conditions that occur in infancy. This study was performed to investigate the frequency of CMA in a group of patients with GERD.

Methods: Eighty-one children with signs and symptoms of GERD were enrolled in this study.