Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases.

The total amount of cellular mitochondrial DNA (mtDNA) varies widely and seems to be related to the nature and metabolic state of tissues and cells in culture. It is not known, however, whether this variation has any significance in vivo, and to which extent it regulates energy production. To better understand the importance of the cellular mtDNA level, we studied the influence of a gradual reduction of mtDNA copy number on oxidative phosphorylation in two models: (a) a control human cell line treated with different concentrations of 2', 3'-dideoxycytidine, a nucleoside analogue that inhibits mtDNA replication by interfering with mitochondrial DNA polymerase gamma, and (b) a cell line derived from a patient presenting mtDNA depletion.

[Febrile seizures].

The febrile seizures (FS) of the child are frequent. Their management is essentially based on the rigorous analysis of their characteristics, the clinical evaluation of the patient like on the collection of the family antecedents. In the case of "simple" FS, the forecast, always favourable, reduce the indications of assessment or treatment, including under possible repetitions.

[Vaccinal status in children with seizures: a retrospective study conducted in the Bordeaux child hospital].

Unlabelled: Vaccination is a common act in medicine. Some serious side effects are always feared in a preventive action, mainly among high-risk patients such as epileptic children or children having already experienced a seizure.

Objectives: To study consequences of such background on the vaccine medical practice.

[Rehospitalization of very preterm infants in the first year of life. Comparison of 2 groups: 1997 and 2002].

Objective: The aim of the study was to compare the rehospitalization rate in the first year of life between 2 groups of very preterm infants born on 1997 and 2002; then we compared the very preterm infants' rehospitalization rate between our retrospective 1997 group and literature (including French cohort Epipage).

Patients And Methods: Our retrospective study included all neonates born
Results: Respectively 29.

[Attachment and prematurity].

The path leading from the desire for a child, his or her birth to the very meeting with the newborn is pregnant with psychic experiences. Among the different experiences punctuating the way is found the process of attachment, that which is necessary to the establishing and structuring the link between the newborn, his or her mother, father and family. Prematurity, and along with it the receiving the premature babies in intensive care or neonatology units, modify the conditions of this meeting, in other word this getting to know one's baby.

[Pediatric emergency department policy. Implementation and management of the resuscitation room].

The pediatric resuscitation room is the place where children suffering from vital distress are cared for in the emergency unit. Recommendations for its organization, functioning and evaluation have been ruled on by experts from six medical societies involved in these emergencies. They concern all the hospital's physicians, nurses and administrative directors.

Minimal effective dose of indomethacin for the treatment of patent ductus arteriosus in preterm infants.

The aim of this study was to determine if it was possible to decrease the number of boluses of indomethacin for the treatment of patent ductus arteriosus. This retrospective study included 46 preterm neonates (<34 weeks' GA) who had had an ultrasound diagnosis predictive of subsequent symptomatic patent ductus arteriosus. All patients had received a daily intravenous doses of indomethacin, 0.

[Respiratory emergencies in infants].

Respiratory distress in childhood is a frequent cause of admission to the emergency department. The initial management requires a rapid clinical evaluation in order to initiate appropriate interventions, which will improve respiratory status, and avoid cardiac arrest and hypoxic encephalopathy. There are many possible etiologies but in the vast majority of cases the following conditions are observed: nasal obstruction before 3 months and laryngitis after 6 months.

[Neonatal nonbacterial thrombotic endocarditis].

Unlabelled: Nonbacterial thrombotic endocarditis is not widely known in neonates.

Case Reports: We report three new cases which illustrate some specific aspects of this pathology. Respiratory distress with severe pulmonary hypertension, systemic hypotension and disseminated intravascular coagulopathy in a full-term newborn were characteristic findings.

[Intrapleural fibrinolytic treatment and infectious pleuresies: three pediatric cases].

Unlabelled: Intrapleural instillation of fibrinolytic agents has been proposed for the treatment of loculated pleural effusions, or whenever the biochemical characteristics of the pleural fluid (pH, glucose level, LDH) indicate the risk of a complicated outcome due to a pleural effusion with complications and the possible development of empyema. At present, there is no consensus regarding the use of intrapleural fibrinolytic agents in children.

Case Reports: In this study, the successful treatment by fibrinolytic agents and standard drainage are successfully performed in three children with a pleural effusion due to an infection.

[Neonatal staphylococcal epidermolysis due to maternal-fetal transmission].

Introduction: The staphylococcal scalded skin syndrome (SSSS) is due to exfoliative toxins A or B excreted by some strains of Staphylococcus aureus. This syndrome is exceptional in the first hours of life. We report a case of SSSS due to materno-fetal infection.