Moving ecological tree-ring big data forwards: Limitations, data integration, and multidisciplinarity.

In recent years, tree-ring databases have emerged as a remarkable resource for ecological research, allowing us to address ecological questions at unprecedented temporal and spatial scales. However, concerns regarding big tree-ring data limitations and risks have also surfaced, leading to questions about their potential to be representative of long-term forest responses. Here, we highlight three paths of action to improve on tree-ring databases in ecology: 1) Implementing consistent bias analyses in large dendroecological databases and promoting community-driven data to address data limitations, 2) Encouraging the integration of tree-ring data with other ecological datasets, and 3) Promoting theory-driven, mechanistic dendroecological research.

DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats.

Sirtuins are the NAD -dependent class III lysine deacylases (KDACs). Members of this family have been linked to longevity and a wide array of different diseases, motivating the pursuit of sirtuin modulator compounds. Sirtuin 6 (SIRT6) is a primarily nuclear KDAC that deacetylates histones to facilitate gene repression.

Asymmetric effects of hydroclimate extremes on eastern US tree growth: Implications on current demographic shifts and climate variability.

Forests around the world are experiencing changes due to climate variability and human land use. How these changes interact and influence the vulnerability of forests are not well understood. In the eastern United States, well-documented anthropogenic disturbances and land-use decisions, such as logging and fire suppression, have influenced forest species assemblages, leading to a demographic shift from forests dominated by xeric species to those dominated by mesic species.

Increasing forest carbon sinks in cold and arid northeastern Tibetan Plateau.

Arid forest lands account for 6 % of the world's forest area, but their carbon density and carbon storage capacity have rarely been assessed. Forest inventories provide estimates of forest stock and biomass carbon density, improve our understanding of the carbon cycle, and help us develop sustainable forest management policies in the face of climate change. Here, we carried out three forest inventories at five-year intervals from 2006 to 2016 in 104 permanent sample plots covering the Qinghai spruce (Picea crassifolia) distribution in the north slope of Qilian Mountains, northeastern Tibetan Plateau.

Reassessment of growth-climate relations indicates the potential for decline across Eurasian boreal larch forests.

Larch, a widely distributed tree in boreal Eurasia, is experiencing rapid warming across much of its distribution. A comprehensive assessment of growth on warming is needed to comprehend the potential impact of climate change. Most studies, relying on rigid calendar-based temperature series, have detected monotonic responses at the margins of boreal Eurasia, but not across the region.

Mapping the Central Sulcus Extraoperatively Using Stereoelectroencephalography: A New Application of an Established Method.

Purpose: Central sulcus localization is undertaken intraoperatively with subdural electrodes through a phase reversal technique using somatosensory evoked potentials from sensorimotor cortices. Extraoperative central sulcus localization using stereoelectroencephalography has not been described previously.

Methods: Six pediatric patients (aged 12-18 years, 50% females) were investigated with stereoelectroencephalography.

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.

Protein-protein interactions that involve recognition of short peptides are critical in cellular processes. Protein-peptide interaction surface areas are relatively small and shallow, and there are often overlapping specificities in families of peptide-binding domains. Therefore, dissecting selectivity determinants can be challenging.

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.

Protein-protein interactions that include recognition of short sequences of amino acids, or peptides, are critical in cellular processes. Protein-peptide interaction surface areas are relatively small and shallow, and there are often overlapping specificities in families of peptide-binding domains. Therefore, dissecting selectivity determinants can be challenging.

Impacts of climate and tree morphology on tree-ring stable isotopes in central Mongolia.

Recent climate extremes in Mongolia have ignited a renewed interest in understanding past climate variability over centennial and longer time scales across north-central Asia. Tree-ring width records have been extensively studied in Mongolia as proxies for climate reconstruction, however, the climate and environmental signals of tree-ring stable isotopes from this region need to be further explored. Here, we evaluated a 182-year record of tree-ring δ13C and δ18O from Siberian Pine (Pinus sibirica Du Tour) from a xeric site in central Mongolia (Khorgo Lava) to elucidate the environmental factors modulating these parameters.

Warm springs alter timing but not total growth of temperate deciduous trees.

As the climate changes, warmer spring temperatures are causing earlier leaf-out and commencement of CO uptake in temperate deciduous forests, resulting in a tendency towards increased growing season length and annual CO uptake. However, less is known about how spring temperatures affect tree stem growth, which sequesters carbon in wood that has a long residence time in the ecosystem. Here we show that warmer spring temperatures shifted stem diameter growth of deciduous trees earlier but had no consistent effect on peak growing season length, maximum growth rates, or annual growth, using dendrometer band measurements from 440 trees across two forests.

Efficacy of long-term indomethacin therapy in prolonging pregnancy after fetoscopic laser surgery for twin-to-twin transfusion syndrome: a collaborative cohort study.

Objective: To evaluate the efficacy of long-term indomethacin therapy (LIT) in prolonging pregnancy and reducing spontaneous preterm birth (PTB) in patients undergoing fetoscopic laser surgery (FLS) for the management of twin-to-twin transfusion syndrome (TTTS).

Design: Retrospective cohort study of prospectively collected data.

Setting: Collaborative multicentre study.

Joint effects of climate, tree size, and year on annual tree growth derived from tree-ring records of ten globally distributed forests.

Tree rings provide an invaluable long-term record for understanding how climate and other drivers shape tree growth and forest productivity. However, conventional tree-ring analysis methods were not designed to simultaneously test effects of climate, tree size, and other drivers on individual growth. This has limited the potential to test ecologically relevant hypotheses on tree growth sensitivity to environmental drivers and their interactions with tree size.

Peak radial growth of diffuse-porous species occurs during periods of lower water availability than for ring-porous and coniferous trees.

Climate models project warmer summer temperatures will increase the frequency and heat severity of droughts in temperate forests of Eastern North America. Hotter droughts are increasingly documented to affect tree growth and forest dynamics, with critical impacts on tree mortality, carbon sequestration and timber provision. The growing acknowledgement of the dominant role of drought timing on tree vulnerability to water deficit raises the issue of our limited understanding of radial growth phenology for most temperate tree species.

Increased water use efficiency leads to decreased precipitation sensitivity of tree growth, but is offset by high temperatures.

Both increases in temperature and changes in precipitation may limit future tree growth, but rising atmospheric CO could offset some of these stressors through increased plant Water Use Efficiency (WUE). The net balance between the negative impacts of climate change and positive effects of CO on tree growth is crucial for ecotones, where increased climate stress could drive mortality and shifts in range. Here, we quantify the effects of climate, stand structure, and rising CO on both annual tree-ring growth increment and intrinsic WUE (iWUE) at a savanna-forest boundary in the Upper Midwest United States.

Old forests and old carbon: A case study on the stand dynamics and longevity of aboveground carbon.

Most information on the ecology of oak-dominated forests in Europe comes from forests altered for centuries because remnants of old-growth forests are rare. Disturbance and recruitment regimes in old-growth forests provide information on forest dynamics and their effects on long-term carbon storage. In an old-growth Quercus petraea forest in northwestern Spain, we inventoried three plots and extracted cores from 166 live and dead trees across canopy classes (DBH ≥ 5 cm).

Climate sensitivity of understory trees differs from overstory trees in temperate mesic forests.

The response of understory trees to climate variability is key to understanding current and future forest dynamics. However, analyses of climatic effects on tree growth have primarily focused on the upper canopy, leaving understory dynamics unresolved. We analyzed differences in climate sensitivity based on canopy position of four common tree species (Acer rubrum, Fagus grandifolia, Quercus rubra, and Tsuga canadensis) using growth information from 1,084 trees across eight sites in the northeastern United States.

Evidence of unprecedented rise in growth synchrony from global tree ring records.

Changes in the temporal coherence between populations, which can influence their stability, resilience and persistence, remain a critical uncertainty of climate change. Recent studies have documented increasing spatial synchrony between populations at continental scales and linked it to anthropogenic climate change. However, the lack of long-term and global baseline perspectives on spatial synchrony presents a challenge to understanding the importance of these trends.

Tree height and leaf drought tolerance traits shape growth responses across droughts in a temperate broadleaf forest.

As climate change drives increased drought in many forested regions, mechanistic understanding of the factors conferring drought tolerance in trees is increasingly important. The dendrochronological record provides a window through which we can understand how tree size and traits shape growth responses to droughts. We analyzed tree-ring records for 12 species in a broadleaf deciduous forest in Virginia (USA) to test hypotheses for how tree height, microenvironment characteristics, and species' traits shaped drought responses across the three strongest regional droughts over a 60-yr period.

Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis.

Identification of the molecular networks that facilitated the evolution of multicellular animals from their unicellular ancestors is a fundamental problem in evolutionary cellular biology. Choanoflagellates are recognized as the closest extant nonmetazoan ancestors to animals. These unicellular eukaryotes can adopt a multicellular-like "rosette" state.

The Effect of Inspiratory Muscle Training on Duchenne Muscular Dystrophy: A Meta-analysis.

Purpose: This study reports the respiratory muscle training effect on strength and endurance in individuals with Duchenne muscular dystrophy.

Methods: Articles published from 1984 to 2017 were reviewed. Six articles met the inclusion criteria that included within-subject control or between-subject control group, participants with a diagnosis of only Duchenne muscular dystrophy, participation in respiratory muscle training intervention, and outcome measures of endurance and strength.

Strong link between large tropical volcanic eruptions and severe droughts prior to monsoon in the central Himalayas revealed by tree-ring records.

Large tropical volcanic eruptions can cause short-term global cooling. However, little is known whether large tropical volcanic eruptions, like the one in Tambora/Indonesia in 1815, cause regional hydroclimatic anomalies. Using a tree-ring network of precisely dated Himalayan birch in the central Himalayas, we reconstructed variations in the regional pre-monsoon precipitation back to 1650 CE.

Snowmelt and early to mid-growing season water availability augment tree growth during rapid warming in southern Asian boreal forests.

Boreal forests are facing profound changes in their growth environment, including warming-induced water deficits, extended growing seasons, accelerated snowmelt, and permafrost thaw. The influence of warming on trees varies regionally, but in most boreal forests studied to date, tree growth has been found to be negatively affected by increasing temperatures. Here, we used a network of Pinus sylvestris tree-ring collections spanning a wide climate gradient the southern end of the boreal forest in Asia to assess their response to climate change for the period 1958-2014.

A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults.

Objective: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used to generate new longitudinal results based on comparable construct-level measurements and identical statistical models and to facilitate replication and research synthesis.