Publications by authors named "Pearman E"
Background: Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age.
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- School-based health services may inadvertently exclude children with disabilities, while community-based approaches provide a more inclusive option for addressing their needs.
- The study focuses on assessing disability prevalence among children aged 5-17 in Malawi and compares the effectiveness of school-based deworming (SBD) versus community-based deworming (CBD) for treating soil-transmitted helminths in these children.
- Findings show a 3.3% disability prevalence, mainly affecting hearing, remembering, and communication, with boys more likely to have disabilities, which corresponded with lower school attendance and poorer health outcomes.
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- Soil-transmitted helminth infections lead to significant health issues in low-and-middle-income countries, and WHO recommends periodic deworming, especially for children and women of reproductive age.
- The study explored factors affecting the effectiveness of community-wide mass drug administration (cMDA) for deworming in high-coverage versus low-coverage areas in Benin, India, and Malawi using both qualitative and quantitative methods.
- Eleven key factors, including community experiences with previous programs and women's decision-making authority, were identified as significant in determining the success of cMDA coverage.
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- The study compares patient-reported outcomes (PROs) for localized prostate cancer at diagnosis across different countries, suggesting that treatment recommendations may vary despite similar patient profiles.
- The analysis included data from 13,483 men across seven regions, using EPIC-26 scores to evaluate differences before treatment based on various approaches like radical prostatectomy and radiotherapy.
- Findings showed significant variation in sexual health scores, while urinary incontinence and bowel domains had higher scores and were more consistent across regions, indicating overall good outcomes in these areas.
Article Synopsis
- Soil Transmitted Helminths (STH) infect over 1.5 billion people worldwide, leading to significant health issues like anemia and stunting, and causing around 1.9 million Disability-Adjusted Life Years (DALYs) lost annually.
- The DeWorm3 trial, conducted in Benin, India, and Malawi, aims to evaluate the effectiveness of community-wide mass drug administration (MDA) for STH, as opposed to the traditional school-based deworming (SBD) methods.
- Analysis of reporting from the DeWorm3 trial reveals that school-level SBD coverage is likely overestimated when compared to individual-level surveys, with actual coverage rates dropping significantly in all study sites after corrections for
Purpose: To detail the process for importing a defined data set into a centralized global registry via a secure file transfer platform and to understand the barriers to the establishment of a centralized global registry.
Results: A bespoke solution was developed to allow transmission of data from international local data centers to a centralized repository. Data elements included in the import template were drawn from existing International Consortium for Health Outcome Measurement variables and refined to ensure accurate benchmarking as well as feasibility in data completeness.
In humans, immunity to Plasmodium sp. generally takes the form of protection from symptomatic malaria (i.e.
View Article and Find Full Text PDFMouse models have demonstrated utility in delineating the mechanisms underlying many aspects of malaria immunology and physiology. The most common mouse models of malaria employ the rodent-specific parasite species , , and , which elicit distinct pathologies and immune responses and are used to model different manifestations of human disease. culture methods are not well developed for rodent parasites, which thus require maintenance.
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