International society of sports nutrition position stand: nutrition and weight cut strategies for mixed martial arts and other combat sports.

Following an extensive literature review, the International Society of Sports Nutrition (ISSN) has developed an official position on nutritional and weight cut strategies for combat sports. The type of combat sport, length of the fight camp, and time between weigh-in and competition are factors influencing nutritional and weight cut strategies. The following 16 points constitute the Position Statement of the Society; the Research Committee has approved them.

"Common sense is hard work" but benefits from persistent collaboration: Lessons learnt from the development of The Collaborative Network for European Clinical Trials for Children (c4c) to support the conduct of paediatric clinical trials of medicines.

Introduction: The Collaborative Network for European Clinical Trials for Children (c4c) is a public private partnership with a developed infrastructure across European sites to support the design and conduct of multi-national academic and industry paediatric clinical trials. This paper aims to review the learning points identified during co-development of c4c processes by academic and industry partners.

Methods: Study metrics were recorded.

The Impact of Rapid Weight Regain on Fight Outcomes in Bellator Mixed Martial Arts Athletes.

Objectives: This study aimed to evaluate the effect of rapid weight regain on the fight outcomes in professional mixed martial arts (MMA) athletes competing in Bellator.

Materials And Methods: Twenty fighters (16 male and four female fighters) were included in the analysis. Official weigh-in and fight-night weights were recorded, and percentage weight regain was calculated.

Preservation of organic carbon in marine sediments sustained by sorption and transformation processes.

Controls on organic carbon preservation in marine sediments remain controversial but crucial for understanding past and future climate dynamics. Here we develop a conceptual-mathematical model to determine the key processes for the preservation of organic carbon. The model considers the major processes involved in the breakdown of organic carbon, including dissolved organic carbon hydrolysis, mixing, remineralization, mineral sorption and molecular transformation.

A critical evaluation of psilocybin-assisted therapy protocol components from clinical trial patients, facilitators, and caregivers.

Psilocybin-assisted therapy (PAT) is an experimental treatment with transformative promise. Developing standards for PAT psychotherapy protocols is a priority, but psychotherapeutic protocol components of PAT have been subjected to little rigorous research. This study was designed to assess protocol components in a trial of PAT.

Analyzing the Impact of Various Jump Load Intensities on Countermovement Jump Metrics: A Comparison of Average, Peak, and Peak-to-Average Ratios in Force-Based Metrics.

The purpose was to create a systematic approach for analyzing data to improve predictive models for fatigue and neuromuscular performance in volleyball, with potential applications in other sports. The study aimed to assess whether average, peak, or peak-to-average ratios of countermovement jump (CMJ) force plate metrics exhibit stronger correlations and determine which metric most effectively predicts performance. Data were obtained from nine division I female volleyball athletes over a season, recording daily jump loads (total jumps, jump counts >38.

Assessment of targets of antibody drug conjugates in SCLC.

Antibody-drug conjugate (ADC) therapy has transformed treatment for several solid tumors, including small cell lung cancer (SCLC). However, significant challenges remain, including systemic toxicity, acquired resistance, and the lack of reliable biomarkers for patient selection. To enhance the effectiveness of ADC therapies in SCLC, we focused on target selection in this study by investigating the expression of ADC targets - SEZ6, DLL3, CD276, and TACSTD2 - in cell lines and patient samples.

Dose-Response Effects of Exercise and Testosterone Replacement Therapy on Body Composition, Lean Mass, and Heart Rate Responses: A Case Report Using Wearable Technology.

The case report explores the effects of testosterone replacement therapy (TRT) on body composition, lean muscle mass, and fat mass, based on the dosage of TRT and exercise intensity in a 40-year-old male. The purpose of this case study was to evaluate the dose-response relationship of TRT and exercise on muscle hypertrophy and fat loss over an eight-month period, using a validated wrist-worn wearable fitness tracker to measure daily physical activity and heart rate (HR)-based exercise intensity. The patient, a trained male with 25 years of consistent exercise experience, reported notable declines in strength and increases in body fat despite maintaining a regular workout routine.

Positional Differences in Jump Loads and Force and Velocity Metrics Throughout a 16-Week Division I Volleyball Season.

The study quantified total and high-intensity jump counts and assessed neuromuscular performance through countermovement jump (CMJ) force and velocity metrics by position. Twelve Division I female athletes (19.6 ± 1.

Countermovement Jumps and Acute to Chronic Workload Ratios in Low, Moderate, and High Jump Load Groups Throughout a Division I Volleyball Season.

Sanders, GJ, Skodinski, S, Cabarkapa, DV, Howard, M, Cabarkapa, D, Kollock, RO, and Peacock, CA. Countermovement jumps and acute to chronic workload ratios in low, moderate, and high jump load groups throughout a Division I volleyball season. J Strength Cond Res XX(X): 000-000, 2024-The purpose of the study was to evaluate the effects of low, moderate, and high jump loads on the acute to chronic workload ratio (ACWR) and neuromuscular fatigue throughout a Division I volleyball season.

Microbial and mineral interactions decouple litter quality from soil organic matter formation.

Current understanding of soil carbon dynamics suggests that plant litter quality and soil mineralogy control the formation of mineral-associated soil organic carbon (SOC). Due to more efficient microbial anabolism, high-quality litter may produce more microbial residues for stabilisation on mineral surfaces. To test these fundamental concepts, we manipulate soil mineralogy using pristine minerals, characterise microbial communities and use stable isotopes to measure decomposition of low- and high-quality litter and mineral stabilisation of litter-C.

UK Foot and Ankle Thromboembolism (UK-FATE).

Aims: Venous thromboembolism (VTE) is a potential complication of foot and ankle surgery. There is a lack of agreement on contributing risk factors and chemical prophylaxis requirements. The primary outcome of this study was to analyze the 90-day incidence of symptomatic VTE and VTE-related mortality in patients undergoing foot and ankle surgery and Achilles tendon (TA) rupture.

Identification of HEPACAM2 as a novel and specific marker of small cell carcinoma.

Background: Small cell lung cancer (SCLC) is the most aggressive neuroendocrine lung cancer, with a dismal 5-year survival rate. No reliable biomarkers or imaging are available for early SCLC detection. In a search for a specific marker of SCLC, this study identified that hepatocyte cell adhesion molecule 2 (HEPACAM2), a member of the immunoglobulin-like superfamily, is highly and specifically expressed in SCLC.

A framework for assessment of adverse events occurring in psychedelic-assisted therapies.

Objective: Despite considerable research examining the efficacy of psychedelic-assisted therapies (PATs) for treating psychiatric disorders, assessment of adverse events (AEs) in PAT research has lagged. Current AE reporting standards in PAT trials are poorly calibrated to features of PAT that distinguish it from other treatments, leaving many potential AEs unassessed.

Methods: A multidisciplinary working group of experts involved in PAT pooled formally and informally documented AEs observed through research experience and published literature.

Early prehabilitation reduces admissions and time in hospital in patients with newly diagnosed lung cancer.

Objectives: Lung cancer is the leading cause of cancer death in the UK. Prehabilitation aims to maximise patient fitness and minimise the negative impact of anticancer treatment. What constitutes prehabilitation before non-surgical anticancer treatment is not well established.

Spiritual health practitioners' contributions to psychedelic assisted therapy: A qualitative analysis.

Background: Psychedelic-assisted therapies hold early promise for treating multiple psychiatric conditions. However, absent standards for the care, teams providing psychedelic-assisted therapy pose a major roadblock to safe administration. Psychedelics often produce spiritually and existentially meaningful experiences, and spiritual health practitioners have been involved in administering psychedelic-assisted therapies in multiple settings, suggesting important qualifications for delivering these therapies.

The Effect of Daily Heart Rate Workloads on Preseason, Midseason, and Postseason Oxygen Consumption in Division I Basketball.

Howard, M, Sanders, GJ, Kollock, RO, Peacock, CA, and Freire, R. The effect of daily heart rate workloads on preseason, midseason, and postseason oxygen consumption in Division I basketball. J Strength Cond Res 38(4): 704-708, 2024-Basketball is a dynamic sport, requiring athletes to elicit a high-level of physical, tactical, technical, and psychological attributes and athletes must possess a robustly trained aerobic energy system.

Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis.

The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics studies to date have focused on comparing primary tumors to the metastatic deposits that define end-stage disease. This static approach means we lack information about the genomic and epigenomic changes that occur during the majority of tumor progression.

Behavior and Fate of Chromium and Carbon during Fe(II)-Induced Transformation of Ferrihydrite Organominerals.

The mobility of chromium (Cr) is controlled by minerals, especially iron (oxyhydr)oxides. The influence of organic carbon (OC) on the mobility and fate of Cr(VI) during Fe(II)-induced transformation of iron (oxyhydr)oxide, however, is still unclear. We investigate how low-weight carboxyl-rich OC influences the transformation of ferrihydrite (Fh) and controls the mobility of Cr(VI/III) in reducing environments and how Cr influences the formation of secondary Fe minerals and the stabilization of OC.

Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.

TP53 and RB1 loss-of-function mutations are common in osteosarcoma. During development, combined loss of TP53 and RB1 function leads to downregulation of autophagy and the aberrant formation of primary cilia, cellular organelles essential for the transmission of canonical Hedgehog (Hh) signaling. Excess cilia formation then leads to hypersensitivity to Hedgehog (Hh) ligand signaling.

Weight cutting in female UFC fighters.

Background: It is common practice for fight sport athletes to use a variety of weight manipulation strategies to compete in desired weight classes. Although numerous studies have highlighted rapid weight loss (RWL) strategies and the magnitude of weight loss, few have focused specifically on weight loss in female fighters. The purpose of this study was to provide descriptive information on professional UFC female fighters engaging in RWL in all women's UFC weight divisions: strawweight (52.

Long-term organic carbon preservation enhanced by iron and manganese.

The balance between degradation and preservation of sedimentary organic carbon (OC) is important for global carbon and oxygen cycles. The relative importance of different mechanisms and environmental conditions contributing to marine sedimentary OC preservation, however, remains unclear. Simple organic molecules can be geopolymerized into recalcitrant forms by means of the Maillard reaction, although reaction kinetics at marine sedimentary temperatures are thought to be slow.

Early prehabilitation in suspected locally advanced and metastatic lung cancer.

Objectives: The most common treatment for locally advanced and metastatic lung cancer is best supportive care. Patients with lung cancer are often comorbid with a high symptom burden. We wanted to assess whether early prehabilitation was feasible in patients with likely lung cancer.