Ocular pathology in trisomy 18 (Edwards' syndrome).

A case of a full-term female with confirmed trisomy 18 who died a few hours after her delivery is presented. In addition to many severe systemic malformations, some ocular findings are described. They include cataract and hypoplasia of optic nerves in both eyes, and juxtapapillary coloboma, retinal dysplasia and Bergmeister's papilla in the left eye.

Malignant teratoid medulloepithelioma manifesting as a black epibulbar mass with expulsive hemorrhage.

An 18-year-old woman with malignant teratoid medulloepithelioma had an epibulbar, brown-black mass associated with expulsive hemorrhage and a limboscleral perforation. Histopathologically, a prominent pigmented neuroepithelial component was present and correlated to the black color of the mass. The massive hemorrhage is apparently related to rupture of necrotic and abnormal vascular channels within the angiomatous component of the neoplasm.

Conjunctival myxoma: a case report.

A rare case of conjunctival myxoma in an 18-year-old female is reported. Clinically it presented as a painless mass located in the nasal bulbar conjunctiva. It was composed of spindle and stellate shaped cells in a loose mucoid stroma.

Ocular metastases from transitional cell carcinoma of the urinary tract.

We report the case of a 69-year-old man with a carcinoma of the breast who developed metastasis to the eye from transitional cell carcinomas in the urinary tract. Ocular metastasis from transitional cell carcinomas in the urinary bladder is extremely rare, and we have not found a report of ocular metastasis from a carcinoma of the ureter or renal pelvis. Although mammary carcinoma is the most common source for metastatic tumors to the eye, the histologic appearance of the metastatic tumor in the eye in the present case was typical of transitional carcinoma of urinary tract origin.

Association between drusen and some of the risk factors for coronary artery disease.

The possible association between coronary artery disease risk factors and drusen was examined in 149 Jewish adults, of both sexes and from different ethnic origins, aged 55 years and above. Areas of drusen were examined 5 degrees and 25 degrees around the macula. Risk factors were examined according to standard procedure used by Lipid Research Clinics.

Association between corneal arcus and some of the risk factors for coronary artery disease.

The relationships between coronary artery disease risk factors and corneal arcus were examined in 150 adults aged 55 years and above of both sexes and from different ethnic origins. The width of the corneal arcus was measured accurately by a digitiser, and the risk factors for coronary artery disease were examined according to the standard procedure used by the Lipid Research Clinics. The results show that the corneal arcus is more frequent in males; the frequency and size of corneal arcus are positively associated with age; there is a positive correlation between the size of corneal arcus and the levels of cholesterol and low-density lipoprotein in males; and that there is negative correlation between corneal arcus and diastolic blood pressure in both sexes.

Computer image analysis of the optic disc.

A computer method for image analysis of the optic disc is presented. Black and white photographic transparencies of the optic disc were scanned by a scanning television camera. The image was digitized into not more than 4,000 x 4,000 points, each representing a value ranging between 0 and 255 gray levels.