How genetic variation was analyzed in phenytoin-induced gingival enlargement using single-nucleotide polymorphism of candidate gene CYP2C9?

Background: Phenytoin-induced gingival overgrowth is an adverse drug reaction affecting few individuals, on phenytoin therapy for its antiepileptic effect. Analysis of genetic variation of CYP2C9*2 gene was done to identify the action of metabolic enzyme cytochrome P 450 on this drug. The main background of this publication is a quick review about one of the molecular techniques used to identify the single-nucleotide polymorphism (SNP) using polymerase chain reaction coupled with restriction fragment length polymorphism (PCR-RFLP).

Cystadenoma in Retromolar Region: A Case Report.

Cystadenoma is a rare benign salivary gland epithelial tumor that is characterized by intraluminal papillary projection. Majority of the tumors are located in minor salivary glands and usually occur in palatal and buccal mucosa, but rarely found in retromolar area. Clinically it is difficult to differentiate it from other minor salivary gland tumors, and diagnosis is chiefly based on characteristic clinical features and immunohistochemistry.

Keratin metaplasia in the epithelial lining of odontogenic cysts.

Objective: To find the prevalence of keratin metaplasia and its relation with clinico-pathological profile of the odontogenic cyst.

Materials And Methods: Odontogenic cysts were studied histologically with special stains to identify the presence of keratin and compared with various parameters such as underlying connective tissue inflammation, average epithelial thickness, and site of the cyst, type of the cyst, age and the sex of the patient.

Results: Of 71 cases of various odontogenic cysts, 26 (36.

Evaluation of serum and salivary lipid profile: A correlative study.

Context: The correlation of serum and salivary lipid profile has been poorly characterized. The most commonly used laboratory diagnostic procedures for lipid profile involve analysis of cellular and chemical constituents of blood/plasma. As a diagnostic aid, saliva offers many advantages over serum.

Procedures to view aberrations--a travel from protein to gene: literature review.

The diagnosis of any pathology is fundamentally based on the microscopic structure of cells and tissues and this remains as the standard by which all other diagnostic tests are measured. In this era, the pathologists are relying on the examination of tissue section stained by histochemical means and it is supported by the advanced immunological, biochemical and molecular techniques. This review will provide the information about one of the way that can be followed to unravel the molecular mechanism in spotting the disease process.

Schwannoma of floor of the mouth.

Schwannoma is an intraoral rare, benign neoplasm arising from and consisting solely of Schwann cells. Its etiology is unknown. It presents as a solitary, slow growing, smooth surfaced, generally asymptomatic firm mass.

Digital approach for measuring dentin translucency in forensic age estimation.

Background: Dentin translucency is best suited for age estimation not only in terms of accuracy but also in terms of simplicity. Conventionally, translucency has been measured using calipers. Computer-based methods have been proposed for the same, although these required the use of custom-built software programs.

The relevance of mast cells in oral squamous cell carcinoma.

Context: The commonly occurring oral neoplasm - Oral Squamous Cell Carcinoma (OSCC) has an association with the chronic inflammation in the adjacent connective tissue. Mast cells are the local residents of the connective tissue. They are said to be pro inflammatory and immune-amplifying in action and they produce mitogenic cytokines.

Oral melanoacanthoma of a rare intraoral site: case report and review of literature.

Oral melanoacanthoma is rare pigmented mucosal lesion that presents most commonly on the buccal mucosa, characterized by sudden appearance and rapid radial growth, thus clinically mimicking malignant melanoma. It was originally described as a mixed tumor of melanocytes and keratinocytes, but appears to be a reactive process; formed in areas prone to trauma, and regressing after the removal of trauma or incomplete excision. The clinical appearance of oral melanoacanthoma is nondiagnostic, and biopsy is mandatory to rule out malignancy.

A comparative analysis of root dentin transparency with known age.

Objective: To correlate dimensions of root transparency and age, and to assess whether transparency is reliable for age estimation of unknown.

Materials And Methods: 50 freshly extracted single rooted permanent teeth from 50 different individuals (27 males and 23 females) were collected and their ground sections of 400 μm were stained with 1% methylene blue. The area of the translucent zone was measured by superimposing a transparent graph paper on the ground section under stereomicroscope.

Morphologic and cytomorphometric analysis of exfoliated buccal mucosal cells in diabetes patients.

Background: It is now known that the disease process of diabetes has effects on various tissues of the body. The following study was done to analyze the effects of diabetes on oral tissues.

Aims: To study the morphology and cytomorphometry of the cells obtained in cytologic smears from the buccal mucosa of diabetic patients.

Role of Barr bodies obtained from oral smears in the determination of sex.

Barr body is an inactivated X chromosome in the normal female somatic cell. Inactivation of these chromosomes is known as Lyonization. Lyonization has both genetic and clinical significance.