[Age-related clinical and laboratory features of patients with occluded main arteries of lower extremities].

The study of clinical and laboratory features of patients with occluded main arteries of lower extremities included morphological characteristics of peripheral blood platelets in patients of different age in the acute period of the disease and after surgical treatment. The results were subjected to correlation analysis versus standard hemostatic parameters. Mean cell volume and enhanced anisocytosis proved the most informative morphological indicators.

[Detection of viral infection markers by radioimmunoassay on flat nonporous fluorosorbents].

The authors present a new variant of radioimmunoassay (RIA) for the detection of markers of viral infections, based on the use of plane nonporous fluorosorbents with organic fluorochromes. An advantage of this method is its fitness to use of not only 125I, but of 3H-ligands as well, for both the indicators may be counted on the fluorosorbent in a standard beta-scintillator in dry flasks without liquid scintillator. The possibility of using 3H makes this method safe.

[The comparative characteristics of the hemodynamic and biochemical indices of the postischemic period in relation to the regimens of brain autohemoperfusion].

In anesthetized cats, comparative characteristics of hemodynamics and biochemical indications of postischemic period in respect to autohemoperfusion with stable blood volume and perfusion pressure, were determined. Cerebral ischemia was caused by the 15-min stop of the perfusing pump or flowmeter and a decrease of systemic arterial blood pressure to 40 ml Hg. In the autohemoperfusion of brain vessels in stable volume or stable arterial pressure, a phasic postischemic phenomenon becomes obvious.

[The role of dopamine in regulating the cerebral circulation in extreme conditions].

In acute experiments on anesthetized cats, the perfusion of dopamine (100 micrograms/kg.min) during 35 minutes after cerebral ischemia inhibited the development of postischemic phenomena. Dopamine was found to exert a considerable effect on the oxidative metabolism in the brain.

[The role of the dopaminergic component in the autoregulatory reaction of the cerebral vessels].

Cerebral blood flow was measured in anesthetised white rats with the hydrogen clearance technique under different levels of arterial blood pressure before and after cerebral ischemia induced with the occlusion of the common carotid arteries during 12 min. The continuous i.v.

[Effect of dopamine on the blood circulation and metabolism in the brain during ischemia].

In acute experiments on anesthetized cats under blood autoperfusion of cerebral and peripheral vessels with a stable volume of blood during cerebral ischemia there was revealed the vascular and metabolic effects of dopamine on cerebral circulation. Administration of dopamine by perfusion in a dose of 100 micrograms/kg/min for 35 min after ischemia inhibited the development of postischemic hypoperfusion of the brain and also eliminated postischemic hypotension. A significant effect of dopamine on oxidative metabolism of the brain was observed.

[The participation of dopamine in the vascular reactions and metabolic processes of the brain].

The dopamine effect on the tension of perfused vessels and the arterial BP depended on its doses in acute experiments on anesthetized cats. Dopaminergic vasodilatory components in perfused vessels responses and the BP were determined with joint blockade of alpha- and beta-receptors. Oxygen and glucose consumption increased in the brain during continuous i.