Publications by authors named "Paz-Cabezas M"
Article Synopsis
- Sarcopenia, or low muscle strength, is a significant comorbidity in patients with acute heart failure (AHF), potentially worsening their prognosis, leading researchers to study its impact on these patients.
- The study analyzed 377 AHF patients and found that 82.23% had low muscle strength, which was associated with older age, cognitive impairment, and poorer functional status.
- Results indicated that patients with low muscle strength had higher rates of readmission and mortality, reinforcing the link between low muscle strength and worse outcomes in AHF.
Article Synopsis
- Heart failure (HF) is a common and serious condition, especially in older adults, leading to many hospital admissions, with acute heart failure (AHF) as a primary diagnosis.
- Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) can enhance survival and quality of life for HF patients, and this study aimed to evaluate their effects on readmission and mortality rates.
- In a study involving 750 patients, only 28% were treated with SGLT2is; those who received the medication were generally younger and had lower left ventricular ejection fractions, and they experienced lower mortality during their hospital admission.
The application of bacterial metagenomic analysis as a biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis of colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). A prospective study was performed on a total of 77 fecal samples from CRC and NSCLC patients and controls.
View Article and Find Full Text PDFColorectal cancer consensus molecular subtypes (CMSs) are widely accepted and constitutes the basis for patient stratification to improve clinical practice. We aimed to find whether miRNAs could reproduce molecular subtypes, and to identify miRNA targets associated to the High-stroma/CMS4 subtype. The expression of 939 miRNAs was analyzed in tumors classified in CMS.
View Article and Find Full Text PDFBackground: MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors.
Objective: To confirm in stage III CRC patients a reported miR signature that was associated to the presence of metastatic disease. To correlate miR expression with microsatellite instability (MSI) and mutations in RAS and BRAF.
Background: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis.
Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19).
Background: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis.
Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19).
Background: There are still few data on the activity and safety of cetuximab-based salvage chemotherapy after immunotherapy (SCAI) in patients with squamous cell cancer of the head and neck (SCCHN).
Materials And Methods: This was a retrospective study of patients with SCCHN who received cetuximab-based SCAI after programmed cell death protein 1 or programmed cell death ligand 1(PD[L]1) inhibitors. Overall response rate (ORR) and disease control rate (DCR) with SCAI and with last chemotherapy before immunotherapy (LCBI) by RECIST 1.
Background: Tumor-infiltrating lymphocytes (TILs), mainly CD8 cytotoxic T lymphocytes (CTL), are linked to immune-mediated control of human cancers and response to immunotherapy. Tumors have nonetheless developed specific mechanisms that selectively restrict T cell entry into the tumor microenvironment. The extracellular superoxide dismutase (SOD3) is an anti-oxidant enzyme usually downregulated in tumors.
View Article and Find Full Text PDFOne drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is an antioxidant enzyme usually repressed in the tumor milieu. Here we show that specific SOD3 re-expression in tumor-associated endothelial cells (ECs) increases doxorubicin (Doxo) delivery into and chemotherapeutic effect on tumors.
View Article and Find Full Text PDF