Publications by authors named "Payton Shoemaker"
Immunohorizons
August 2024
Article Synopsis
- TLRs (Toll-like receptors) start immune responses by using TIR (Toll/IL-1R) domains, but some bacteria have their own TIR proteins to evade immune detection.
- Initial studies on a bacterial TIR from Acinetobacter baumannii revealed structural insights but didn't clarify how it binds NAD, leading to further investigation.
- A collaborative research project involving undergraduates aimed to identify key amino acids for the NADase activity of TIR domains from A. baumannii and E. coli, providing new insights into their function and reaffirming the effectiveness of student-led research experiences.
