Elevated WNT signaling and compromised Hedgehog signaling due to loss of function contribute to the abnormal molar patterning.

Ellis-van Creveld (EVC) syndrome is an autosomal recessive chondrodysplasia. The affected individuals bear a series of skeleton defects, congenital heart septum anomalies, midfacial defects, and dental defects. Previous studies using or mutant mice have characterized the pathological mechanism leading to various types of congenital defects.

Transient impairment of dynamic renal autoregulation in early diabetes mellitus in rats.

Renal autoregulation is impaired in early (1 wk) diabetes mellitus (DM) induced by streptozotocin, but effective in established DM (4 wk). Furthermore nitric oxide synthesis (NOS) inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME) significantly improved autoregulation in early DM but not in established DM. We hypothesized that autoregulation is transiently impaired in early DM because of increased NO availability in the kidney.