Publications by authors named "Payman Nikmehr"
Article Synopsis
- * The review analyzed data from 39 studies involving humans and animals, focusing on the effects of EPs on conditions like arthritis, cancer, autoimmune diseases, and diabetes, among others.
- * The main mechanism of EPs is the induction of oral tolerance, alongside providing oral vaccines and bioactive compounds, indicating their significant potential in addressing chronic and genetic diseases.
Background: We aimed to evaluate the anti-cancer and immune system enhancing properties of Vitamin E succinate (VES) and methylselenic acid (MSA) administration on 4T1 breast tumor model under high-dose methotrexate (HDMTX) therapy and folinic acid (FA) rescue.
Methods: Thirty six 4T1 mammary carcinoma bearing mice were randomly divided into six groups: control (untreated; n = 6), treatment-1 (T1 group; HDMTX; n = 6), T2 (T1 + FA; n = 6), T3 (T2 + MSA; n = 6), T4 (T2 + VES; n = 6) and T5 (T3 + VES; n = 6). On day 21 of the study, all surviving mice were sacrificed and primary tumors and peripheral tissues were examined for histological and gene expression assays.