MicroRNA as a potential diagnostic and prognostic biomarker in brain gliomas: a systematic review and meta-analysis.

Introduction: Brain neoplasms and central nervous system (CNS) disorders, particularly gliomas, have shown a notable increase in incidence over the last three decades, posing significant diagnostic and therapeutic challenges. MicroRNAs (miRNAs) have emerged as promising biomarkers due to their regulatory role in gene expression, offering potential enhancements in glioma diagnosis and prognosis.

Methods: This systematic review and meta-analysis, adhering to PRISMA guidelines, included 25 studies for diagnostic accuracy and 99 for prognostic analysis, published until August 27th, 2023.

Association of PD-L1 Expression on Tumor and Immune Cells with Survival in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Assay Validation.

Unlabelled: Programmed cell death ligand-1 (PD-L1), expressed on both tumor cells (TC) and tumor-associated immune cells (IC), has been shown to be a useful biomarker and predictive of response to anti-PD-L1 agents in certain tumor types. In recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), there is a growing interest in the role of PD-L1 expression on ICs, as well as TCs, for predicting response to immune checkpoint inhibitors. Using pooled data from the phase II HAWK and CONDOR studies, we investigated the association of baseline PD-L1 expression with durvalumab efficacy in patients with R/M HNSCC.

Comparing the effects of external focus of attention and continuous cognitive task on postural control in anterior cruciate ligament reconstructed athletes.

External focus (EF) of attention and continuous cognitive task (CCT) reduced postural sway in young and adult people owing to the automatic process of postural control, but their effects on postural control in athletes with musculoskeletal injury like anterior cruciate ligament (ACL) reconstruction are unclear. The present study aimed to reveal the effects of EF of attention and CCT on postural control in ACL reconstructed (ACL-R) athletes by comparing the pattern of the condition-group interaction between ACL-R and healthy athletes. The participants included healthy athletes (n = 20) and ACL-R athletes (n = 20).

Attentional demands of postural control during single leg stance in patients with anterior cruciate ligament reconstruction.

The aim of this study was to investigate the amount of attention demands of postural control in patients with anterior cruciate ligament-reconstruction (ACL-R), by comparing the pattern of posture-cognition interaction between two groups of ACL-R patients (n=25) and healthy matched controls (n=25). All participants were examined during single-leg stance on a balance board under both single- and dual-task conditions in 4 dynamic balance tests. These tests were standing on the injured and uninjured legs with straight or flexed knees.