Effects of tibolone or continuous combined oestradiol and norethisterone acetate on lipids, high-density lipoprotein subfractions and apolipoproteins in postmenopausal women in a two-year, randomized, double-blind, placebo-controlled trial.

Objective: To compare the effects of (a) tibolone, (b) continuous combined oestrogen plus progestogen and (c) placebo on plasma lipid and lipoprotein markers of cardiovascular risk in healthy postmenopausal women.

Study Design: Randomized, single-centre, placebo-controlled, double-blind study.

Patients: One hundred and one postmenopausal women were randomized (1:1:1) into one of three groups taking daily 2.